2-Pyridinecarboxamide,N-[(4-methylphenyl)methyl]-(9CI)

Base Information

• Chemical Name: 2-Pyridinecarboxamide,N-[(4-methylphenyl)methyl]-(9CI)
• CAS No.: 795283-79-3
• Molecular Formula: C14H14 N2 O
• Molecular Weight: 226.278
• Mol file: 795283-79-3.mol

Synonyms:2-Pyridinecarboxamide,N-[(4-methylphenyl)methyl]-(9CI)

Chemical Property of 2-Pyridinecarboxamide,N-[(4-methylphenyl)methyl]-(9CI)

Chemical Property:

• PSA: 41.99000
• LogP: 2.71090

Purity/Quality:

N-[(4-METHYLPHENYL)METHYL]-2-PYRIDINECARBOXAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Pyridinecarboxamide,N-[(4-methylphenyl)methyl]-(9CI)

There total 2 articles about 2-Pyridinecarboxamide,N-[(4-methylphenyl)methyl]-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

2-Picolinic acid (98-98-6) + para-methylbenzylamine (104-84-7) → N-(4-methylbenzyl)picolinamide (795283-79-3)

Guidance literature:

With tetramethylorthosilicate; In toluene; at 110 ℃; for 2h; Inert atmosphere;

DOI:10.1021/acs.orglett.7b03841

Reference yield:

2-picolinoyl chloride hydrochloride (39901-94-5) + para-methylbenzylamine (104-84-7) → N-(4-methylbenzyl)picolinamide (795283-79-3)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 20 ℃; for 2h;

DOI:10.1002/chem.201202601

Reference yield: 87.0%

N-(4-methylbenzyl)picolinamide (795283-79-3) + diphenyl acetylene (501-65-5) → 6-methyl-3,4-diphenylisoquinoline (1300635-93-1)

Guidance literature:

With N-(2-methoxybenzyl)pyridine-2-amide; oxygen; cobalt(II) diacetate tetrahydrate; at 140 ℃; for 20h; under 760.051 Torr;

DOI:10.1021/acs.orglett.7b00702

upstream raw materials:

2-Picolinic acid

para-methylbenzylamine

2-picolinoyl chloride hydrochloride

Downstream raw materials:

C₁₈H₁₈N₂O₅

N-(4-chlorobenzoyl)-N-(4-methylbenzyl)picolinamide

6-methyl-3,4-diphenylisoquinoline

6-methylisoindolin-1-one