(R)-5-(Biphenyl-4-yloxymethoxy)-2-[(S)-1-(3-nitro-phenyl)-propyl]-3-oxo-5-phenethyl-octanoic acid methyl ester

Base Information

Chemical Name:(R)-5-(Biphenyl-4-yloxymethoxy)-2-[(S)-1-(3-nitro-phenyl)-propyl]-3-oxo-5-phenethyl-octanoic acid methyl ester
CAS No.:215317-19-4
Molecular Formula:C₃₉H₄₃NO₇
Molecular Weight:637.773
Hs Code.:

Synonyms:(R)-5-(Biphenyl-4-yloxymethoxy)-2-[(S)-1-(3-nitro-phenyl)-propyl]-3-oxo-5-phenethyl-octanoic acid methyl ester

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Chemical Property of (R)-5-(Biphenyl-4-yloxymethoxy)-2-[(S)-1-(3-nitro-phenyl)-propyl]-3-oxo-5-phenethyl-octanoic acid methyl ester

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Technology Process of (R)-5-(Biphenyl-4-yloxymethoxy)-2-[(S)-1-(3-nitro-phenyl)-propyl]-3-oxo-5-phenethyl-octanoic acid methyl ester

There total 5 articles about (R)-5-(Biphenyl-4-yloxymethoxy)-2-[(S)-1-(3-nitro-phenyl)-propyl]-3-oxo-5-phenethyl-octanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.2%

: 215317-17-2
(R)-5-(Biphenyl-4-yloxymethoxy)-3-hydroxy-2-[(S)-1-(3-nitro-phenyl)-propyl]-5-phenethyl-octanoic acid methyl ester

: 215317-19-4
(R)-5-(Biphenyl-4-yloxymethoxy)-2-[(S)-1-(3-nitro-phenyl)-propyl]-3-oxo-5-phenethyl-octanoic acid methyl ester

Guidance literature:: With florisil; sodium acetate; pyridinium chlorochromate; In dichloromethane; for 20h; Ambient temperature;
DOI:10.1021/jo9809229

Reference yield:

: 215317-11-6
(R)-3-(2-phenylethyl)-3-[(4-phenylphenoxy)methoxy]hexanol

: 215317-19-4
(R)-5-(Biphenyl-4-yloxymethoxy)-2-[(S)-1-(3-nitro-phenyl)-propyl]-3-oxo-5-phenethyl-octanoic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 98.6 percent / KBr, NaHCO₃, 4-hydroxy-2,2,6,6-tetramethylpiperidinyloxy, NaOCl / H₂O / 1 h / 1 - 5 °C

2: 89.7 percent / NaHMDS / tetrahydrofuran / -90 - -71 °C

3: 99.2 percent / PCC, NaOAc, Florisil / CH₂Cl₂ / 20 h / Ambient temperature

With sodium hypochlorite; florisil; TEMPOL; sodium acetate; sodium hexamethyldisilazane; sodium hydrogencarbonate; pyridinium chlorochromate; potassium bromide; In tetrahydrofuran; dichloromethane; water;
DOI:10.1021/jo9809229

Reference yield:

: 215317-14-9
(R)-3-(2-phenylethyl)-3-[(4-phenylphenoxy)methoxy]hexanal

: 215317-19-4
(R)-5-(Biphenyl-4-yloxymethoxy)-2-[(S)-1-(3-nitro-phenyl)-propyl]-3-oxo-5-phenethyl-octanoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 89.7 percent / NaHMDS / tetrahydrofuran / -90 - -71 °C

2: 99.2 percent / PCC, NaOAc, Florisil / CH₂Cl₂ / 20 h / Ambient temperature

With florisil; sodium acetate; sodium hexamethyldisilazane; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo9809229