2-Methyl-5-nitropyridin-4-ol

Base Information

Chemical Name:2-Methyl-5-nitropyridin-4-ol
CAS No.:18614-67-0
Molecular Formula:C₆H₆N₂O₃
Molecular Weight:154.125
Hs Code.:
European Community (EC) Number:825-231-1
DSSTox Substance ID:DTXSID901308436
Mol file:18614-67-0.mol

Synonyms:2-Methyl-5-nitropyridin-4-ol;18614-67-0;2-methyl-5-nitro-1H-pyridin-4-one;2-Methyl-5-nitro-4-pyridinol;SCHEMBL7549178;DTXSID901308436;DB-356222;EN300-112553;F96670

Suppliers and Price of 2-Methyl-5-nitropyridin-4-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

AK Scientific
2-Methyl-5-nitropyridin-4-ol
100mg
$ 526.00

Total 3 raw suppliers

Chemical Property of 2-Methyl-5-nitropyridin-4-ol

Chemical Property:

XLogP3:0.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:0
Exact Mass:154.03784206
Heavy Atom Count:11
Complexity:272

Purity/Quality:

99% ^*data from raw suppliers

2-Methyl-5-nitropyridin-4-ol ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=CC(=O)C(=CN1)[N+](=O)[O-]

Technology Process of 2-Methyl-5-nitropyridin-4-ol

There total 6 articles about 2-Methyl-5-nitropyridin-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5470-66-6
2-methyl-4-nitropyridine N-oxide

: 18614-67-0
2-methyl-5-nitropyridin-4-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium tert-butylate / 2 h / 80 °C

2.1: acetic acid; iron / 2 h / 120 °C

3.1: nitric acid; sulfuric acid / 16 h / 0 - 65 °C / Sealed tube

3.2: 2 h / 100 °C

With sulfuric acid; potassium tert-butylate; nitric acid; iron; acetic acid;

Reference yield:

: 24103-75-1
4-methoxy-2-methylpyridine

: 18614-67-0
2-methyl-5-nitropyridin-4-ol

: 18614-66-9
2-methyl-3-nitro-4-pyridinol

Guidance literature:: 4-methoxy-2-methylpyridine; With sulfuric acid; nitric acid; at 0 - 65 ℃; for 16h; Sealed tube;

With hydrogen bromide; at 100 ℃; for 2h; Overall yield = 68 %; Overall yield = 250mg;

Reference yield:

: 18614-65-8
2-methyl-4-pyridinol nitrate

: 18614-67-0
2-methyl-5-nitropyridin-4-ol

: 18614-66-9
2-methyl-3-nitro-4-pyridinol

Guidance literature:: With sulfuric acid; nitric acid; at 0 - 130 ℃; Overall yield = 70 %; Overall yield = 1.88 g;
DOI:10.1021/acs.joc.7b00323