2-<(1S)-2-(Benzyloxy)-1-methyl-1-<<<2-(trimethylsilyl)ethyl>sulfonyl>amino>ethyl>-5-methyloxazole-4-carboxylic acid methylamide

Base Information

Chemical Name:2-<(1S)-2-(Benzyloxy)-1-methyl-1-<<<2-(trimethylsilyl)ethyl>sulfonyl>amino>ethyl>-5-methyloxazole-4-carboxylic acid methylamide
CAS No.:171011-99-7
Molecular Formula:C₂₁H₃₃N₃O₅SSi
Molecular Weight:467.662
Hs Code.:

Synonyms:2-<(1S)-2-(Benzyloxy)-1-methyl-1-<<<2-(trimethylsilyl)ethyl>sulfonyl>amino>ethyl>-5-methyloxazole-4-carboxylic acid methylamide

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Chemical Property of 2-<(1S)-2-(Benzyloxy)-1-methyl-1-<<<2-(trimethylsilyl)ethyl>sulfonyl>amino>ethyl>-5-methyloxazole-4-carboxylic acid methylamide

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Technology Process of 2-<(1S)-2-(Benzyloxy)-1-methyl-1-<<<2-(trimethylsilyl)ethyl>sulfonyl>amino>ethyl>-5-methyloxazole-4-carboxylic acid methylamide

There total 10 articles about 2-<(1S)-2-(Benzyloxy)-1-methyl-1-<<<2-(trimethylsilyl)ethyl>sulfonyl>amino>ethyl>-5-methyloxazole-4-carboxylic acid methylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 74-89-5
methylamine

: 171011-86-2
2-<(1S)-2-(Benzyloxy)-1-methyl-1-<<<2-(trimethylsilyl)ethyl>sulfonyl>amino>ethyl>-5-methyloxazole-4-carboxylic acid methyl ester

: 171011-99-7
2-<(1S)-2-(Benzyloxy)-1-methyl-1-<<<2-(trimethylsilyl)ethyl>sulfonyl>amino>ethyl>-5-methyloxazole-4-carboxylic acid methylamide

Guidance literature:: In methanol; at 21 ℃; for 12h;
DOI:10.1021/jo00127a030

Reference yield:

: 168553-64-8
(S)-3-Benzyloxy-2-methyl-2-(2-trimethylsilanyl-ethanesulfonylamino)-propionic acid

: 171011-99-7
2-<(1S)-2-(Benzyloxy)-1-methyl-1-<<<2-(trimethylsilyl)ethyl>sulfonyl>amino>ethyl>-5-methyloxazole-4-carboxylic acid methylamide

Guidance literature:: Multi-step reaction with 4 steps

1: DMAP, bromotripyrrolidinophosphonium hexafluorophosphate

2: Dess-Martin reagent

3: Ph₃P, I₂, NEt₃

4: methanol

With dmap; iodine; Dess-Martin periodane; triethylamine; triphenylphosphine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In methanol;
DOI:10.1055/s-1997-681

Reference yield:

: (2R,3S)-2-<<(2S)-3-(Benzyloxy)-2-methyl-2-<<<2-(trimethylsilyl)ethyl>sulfonyl>amino>propionyl>amino>-3-hydroxybutyric acid methyl ester

: 171011-99-7
2-<(1S)-2-(Benzyloxy)-1-methyl-1-<<<2-(trimethylsilyl)ethyl>sulfonyl>amino>ethyl>-5-methyloxazole-4-carboxylic acid methylamide

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / Dess-Martin periodinate / CH₂Cl₂ / 0.33 h / 21 °C

2: 66 percent / Ph₃P, I₂, NEt₃ / tetrahydrofuran / 1.) -60 deg C, 20 min, 2.) 0 deg C, 2 h

3: 100 percent / methanol / 12 h / 21 °C

With iodine; Dess-Martin periodane; triethylamine; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jo00127a030