(Z)-4-[1-fluoro-2-(4-methoxyphenyl)vinyl]-1-(4-methoxyphenyl)-1H-1,2,3-triazole

Base Information

• Chemical Name: (Z)-4-[1-fluoro-2-(4-methoxyphenyl)vinyl]-1-(4-methoxyphenyl)-1H-1,2,3-triazole
• CAS No.: 1293294-88-8
• Molecular Formula: C₁₈H₁₆FN₃O₂
• Molecular Weight: 325.342

Synonyms:(Z)-4-[1-fluoro-2-(4-methoxyphenyl)vinyl]-1-(4-methoxyphenyl)-1H-1,2,3-triazole

Chemical Property of (Z)-4-[1-fluoro-2-(4-methoxyphenyl)vinyl]-1-(4-methoxyphenyl)-1H-1,2,3-triazole

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

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Technology Process of (Z)-4-[1-fluoro-2-(4-methoxyphenyl)vinyl]-1-(4-methoxyphenyl)-1H-1,2,3-triazole

There total 3 articles about (Z)-4-[1-fluoro-2-(4-methoxyphenyl)vinyl]-1-(4-methoxyphenyl)-1H-1,2,3-triazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-{fluoro[1-(4-methoxyphenyl)-1H-1,2,3-triazol-4-yl]methylsulfonyl}benzo[d]-thiazole (1293294-65-1) + 4-methoxy-benzaldehyde (123-11-5) → (E)-4-[1-fluoro-2-(4-methoxyphenyl)vinyl]-1-(4-methoxyphenyl)-1H-1,2,3-triazole + (Z)-4-[1-fluoro-2-(4-methoxyphenyl)vinyl]-1-(4-methoxyphenyl)-1H-1,2,3-triazole (1293294-88-8)

Guidance literature:

With lithium hexamethyldisilazane; In tetrahydrofuran; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; N,N-dimethyl-formamide; at -78 ℃; for 0.0833333h; optical yield given as %de; Inert atmosphere;

DOI:10.1039/c0cc05083k

Reference yield:

p-methoxy-phenylazide (2101-87-3) → (E)-4-[1-fluoro-2-(4-methoxyphenyl)vinyl]-1-(4-methoxyphenyl)-1H-1,2,3-triazole + (Z)-4-[1-fluoro-2-(4-methoxyphenyl)vinyl]-1-(4-methoxyphenyl)-1H-1,2,3-triazole (1293294-88-8)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrakis(actonitrile)copper(I) hexafluorophosphate; silver tetrafluoroborate / methanol; dichloromethane / 20 °C

2: lithium hexamethyldisilazane / tetrahydrofuran; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; N,N-dimethyl-formamide / 0.08 h / -78 °C / Inert atmosphere

With silver tetrafluoroborate; tetrakis(actonitrile)copper(I) hexafluorophosphate; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; dichloromethane; N,N-dimethyl-formamide; 1: Huisgen ligation reaction / 2: Julia Olefin synthesis;

DOI:10.1039/c0cc05083k

Reference yield:

4-methoxyphenylboronic acid (5720-07-0) → (E)-4-[1-fluoro-2-(4-methoxyphenyl)vinyl]-1-(4-methoxyphenyl)-1H-1,2,3-triazole + (Z)-4-[1-fluoro-2-(4-methoxyphenyl)vinyl]-1-(4-methoxyphenyl)-1H-1,2,3-triazole (1293294-88-8)

Guidance literature:

Multi-step reaction with 3 steps

1: copper(ll) sulfate pentahydrate; sodium azide / methanol / 5 h / 20 °C

2: tetrakis(actonitrile)copper(I) hexafluorophosphate; silver tetrafluoroborate / methanol; dichloromethane / 20 °C

3: lithium hexamethyldisilazane / tetrahydrofuran; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; N,N-dimethyl-formamide / 0.08 h / -78 °C / Inert atmosphere

With silver tetrafluoroborate; sodium azide; copper(ll) sulfate pentahydrate; tetrakis(actonitrile)copper(I) hexafluorophosphate; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; dichloromethane; N,N-dimethyl-formamide; 2: Huisgen ligation reaction / 3: Julia Olefin synthesis;

DOI:10.1039/c0cc05083k

upstream raw materials:

2-{fluoro[1-(4-methoxyphenyl)-1H-1,2,3-triazol-4-yl]methylsulfonyl}benzo[d]-thiazole

4-methoxy-benzaldehyde

4-methoxyphenylboronic acid

p-methoxy-phenylazide

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