4-(cyano-dimethyl-methyl)-N-[1-dimethylamino-meth-(E)-ylidene]-2-fluoro-6-methylbenzamide

Base Information

Chemical Name:4-(cyano-dimethyl-methyl)-N-[1-dimethylamino-meth-(E)-ylidene]-2-fluoro-6-methylbenzamide
CAS No.:1360056-33-2
Molecular Formula:C₁₅H₁₈FN₃O
Molecular Weight:275.326
Hs Code.:

Synonyms:4-(cyano-dimethyl-methyl)-N-[1-dimethylamino-meth-(E)-ylidene]-2-fluoro-6-methylbenzamide

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Chemical Property of 4-(cyano-dimethyl-methyl)-N-[1-dimethylamino-meth-(E)-ylidene]-2-fluoro-6-methylbenzamide

Chemical Property:

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Technology Process of 4-(cyano-dimethyl-methyl)-N-[1-dimethylamino-meth-(E)-ylidene]-2-fluoro-6-methylbenzamide

There total 9 articles about 4-(cyano-dimethyl-methyl)-N-[1-dimethylamino-meth-(E)-ylidene]-2-fluoro-6-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1360056-32-1
4-(cyano-dimethyl-methyl)-2-fluoro-6-methylbenzamide

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: 1360056-33-2
4-(cyano-dimethyl-methyl)-N-[1-dimethylamino-meth-(E)-ylidene]-2-fluoro-6-methylbenzamide

Guidance literature:: In tetrahydrofuran; at 63 ℃; for 3h;

Reference yield:

: 1360056-27-4
4,4-dimethyl-2-(2,4,6-trifluorophenyl)-4,5-dihydro-1,3-oxazole

: 1360056-33-2
4-(cyano-dimethyl-methyl)-N-[1-dimethylamino-meth-(E)-ylidene]-2-fluoro-6-methylbenzamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: diethyl ether; tetrahydrofuran / 0 - 20 °C

2.1: potassium hexamethylsilazane / toluene; tetrahydrofuran / -20 - 15 °C / Inert atmosphere

3.1: acetonitrile / 63 °C

4.1: sodium hydroxide; water / methanol / 1 h / 80 °C

4.2: pH 1

5.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 2.75 h

5.2: 4 h

6.1: tetrahydrofuran / 3 h / 63 °C

With water; potassium hexamethylsilazane; 1,1'-carbonyldiimidazole; sodium hydroxide; In tetrahydrofuran; methanol; diethyl ether; toluene; acetonitrile;

Reference yield:

: 1360056-29-6
2-[4-(4,4-dimethyl-4,5-dihydro-1,3-oxazol-2-yl)-3-fluoro-5-methylphenyl]-2-methylpropionitrile

: 1360056-33-2
4-(cyano-dimethyl-methyl)-N-[1-dimethylamino-meth-(E)-ylidene]-2-fluoro-6-methylbenzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: acetonitrile / 63 °C

2.1: sodium hydroxide; water / methanol / 1 h / 80 °C

2.2: pH 1

3.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 2.75 h

3.2: 4 h

4.1: tetrahydrofuran / 3 h / 63 °C

With water; 1,1'-carbonyldiimidazole; sodium hydroxide; In tetrahydrofuran; methanol; acetonitrile;