N-[3-[3-(4-Phenyl-1-piperazinyl)propoxy]phenyl]formamide

Base Information

Chemical Name:N-[3-[3-(4-Phenyl-1-piperazinyl)propoxy]phenyl]formamide
CAS No.:78702-83-7
Molecular Formula:C₂₀H₂₅N₃O₂
Molecular Weight:339.437
Hs Code.:
DSSTox Substance ID:DTXSID801200530

Synonyms:SCHEMBL11358561;N-[3-[3-(4-Phenyl-1-piperazinyl)propoxy]phenyl]formamide;DTXSID801200530;78702-83-7

Suppliers and Price of N-[3-[3-(4-Phenyl-1-piperazinyl)propoxy]phenyl]formamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[3-[3-(4-Phenyl-1-piperazinyl)propoxy]phenyl]formamide

Chemical Property:

XLogP3:3.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:7
Exact Mass:339.19467705
Heavy Atom Count:25
Complexity:379

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1CN(CCN1CCCOC2=CC=CC(=C2)NC=O)C3=CC=CC=C3

Technology Process of N-[3-[3-(4-Phenyl-1-piperazinyl)propoxy]phenyl]formamide

There total 4 articles about N-[3-[3-(4-Phenyl-1-piperazinyl)propoxy]phenyl]formamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 64-18-6
formic acid

: 85868-45-7
1-(3-aminophenoxy)-3-1-(N⁴-phenylpiperazinyl)>propane

: 78702-83-7
N-{3-[3-(4-Phenyl-piperazin-1-yl)-propoxy]-phenyl}-formamide

Guidance literature:: With acetic anhydride; In tetrahydrofuran; 1.) 50 deg C, 1 h, 2.) room temperature;
DOI:10.1021/jm00403a022

Reference yield:

: 92-54-6
4-phenyl-1-piperazine

: 78702-83-7
N-{3-[3-(4-Phenyl-piperazin-1-yl)-propoxy]-phenyl}-formamide

Guidance literature:: Multi-step reaction with 4 steps

1: aq. NaOH / 60 h / Ambient temperature

2: 72 percent / sodium isopropoxide / propan-2-ol / Heating

3: 93 percent / aq. HCl / 6 h / Heating

4: 86 percent / acetic anhydridie / tetrahydrofuran / 1.) 50 deg C, 1 h, 2.) room temperature

With hydrogenchloride; sodium hydroxide; sodium isopropylate; acetic anhydride; In tetrahydrofuran; isopropyl alcohol;
DOI:10.1021/jm00403a022

Reference yield:

: 10599-17-4
1-(3-chloropropyl)-4-phenylpiperazine

: 78702-83-7
N-{3-[3-(4-Phenyl-piperazin-1-yl)-propoxy]-phenyl}-formamide

Guidance literature:: Multi-step reaction with 3 steps

1: 72 percent / sodium isopropoxide / propan-2-ol / Heating

2: 93 percent / aq. HCl / 6 h / Heating

3: 86 percent / acetic anhydridie / tetrahydrofuran / 1.) 50 deg C, 1 h, 2.) room temperature

With hydrogenchloride; sodium isopropylate; acetic anhydride; In tetrahydrofuran; isopropyl alcohol;
DOI:10.1021/jm00403a022