[(3aS,6aR)-2,2-dioxido-5-[(1R)-1-phenylethyl]tetrahydro-1H-thieno[3,4-c]pyrrol-3a(3H)-yl]bis(4-methoxyphenyl)methanol

Base Information

• Chemical Name: [(3aS,6aR)-2,2-dioxido-5-[(1R)-1-phenylethyl]tetrahydro-1H-thieno[3,4-c]pyrrol-3a(3H)-yl]bis(4-methoxyphenyl)methanol
• CAS No.: 607405-09-4
• Molecular Formula: C₂₉H₃₃NO₅S
• Molecular Weight: 507.651

Synonyms:[(3aS,6aR)-2,2-dioxido-5-[(1R)-1-phenylethyl]tetrahydro-1H-thieno[3,4-c]pyrrol-3a(3H)-yl]bis(4-methoxyphenyl)methanol

Chemical Property of [(3aS,6aR)-2,2-dioxido-5-[(1R)-1-phenylethyl]tetrahydro-1H-thieno[3,4-c]pyrrol-3a(3H)-yl]bis(4-methoxyphenyl)methanol

Chemical Property:

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Technology Process of [(3aS,6aR)-2,2-dioxido-5-[(1R)-1-phenylethyl]tetrahydro-1H-thieno[3,4-c]pyrrol-3a(3H)-yl]bis(4-methoxyphenyl)methanol

There total 3 articles about [(3aS,6aR)-2,2-dioxido-5-[(1R)-1-phenylethyl]tetrahydro-1H-thieno[3,4-c]pyrrol-3a(3H)-yl]bis(4-methoxyphenyl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

4-methoxyphenyl magnesium bromide (13139-86-1) + methyl (3aS,6aR)-5-[(1R)-1-phenylethyl]tetrahydro-1H-thieno[3,4-c]pyrrole-3a(3H)-carboxylate 2,2-dioxide (607405-07-2) → [(3aS,6aR)-2,2-dioxido-5-[(1R)-1-phenylethyl]tetrahydro-1H-thieno[3,4-c]pyrrol-3a(3H)-yl]bis(4-methoxyphenyl)methanol (607405-09-4)

Guidance literature:

In tetrahydrofuran; diethyl ether; for 5h;

DOI:10.1002/ejoc.200300172

Reference yield:

methyl 2,5-dihydrothiophene-S,S-dioxide-3-carboxylate (67488-50-0) → [(3aS,6aR)-2,2-dioxido-5-[(1R)-1-phenylethyl]tetrahydro-1H-thieno[3,4-c]pyrrol-3a(3H)-yl]bis(4-methoxyphenyl)methanol (607405-09-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 35 percent / trifluoroacetic acid / CH₂Cl₂ / 0.5 h / 20 °C

2: 62 percent / tetrahydrofuran; diethyl ether / 5 h

With trifluoroacetic acid; In tetrahydrofuran; diethyl ether; dichloromethane;

DOI:10.1002/ejoc.200300172

Reference yield:

(R)-N-(1-phenylethyl)-N-(methoxymethyl)-N-(trimethylsilylmethyl)amine (133407-38-2) → [(3aS,6aR)-2,2-dioxido-5-[(1R)-1-phenylethyl]tetrahydro-1H-thieno[3,4-c]pyrrol-3a(3H)-yl]bis(4-methoxyphenyl)methanol (607405-09-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 35 percent / trifluoroacetic acid / CH₂Cl₂ / 0.5 h / 20 °C

2: 62 percent / tetrahydrofuran; diethyl ether / 5 h

With trifluoroacetic acid; In tetrahydrofuran; diethyl ether; dichloromethane;

DOI:10.1002/ejoc.200300172

upstream raw materials:

4-methoxyphenyl magnesium bromide

methyl (3aS,6aR)-5-[(1R)-1-phenylethyl]tetrahydro-1H-thieno[3,4-c]pyrrole-3a(3H)-carboxylate 2,2-dioxide

methyl 2,5-dihydrothiophene-S,S-dioxide-3-carboxylate

(R)-N-(1-phenylethyl)-N-(methoxymethyl)-N-(trimethylsilylmethyl)amine

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