4-METHOXYBENZALDEHYDE SEMICARBAZONE

Base Information

• Chemical Name: 4-METHOXYBENZALDEHYDE SEMICARBAZONE
• CAS No.: 120445-53-6
• Molecular Formula: C₉H₁₁N₃O₂
• Molecular Weight: 193.205
• Mol file: 120445-53-6.mol

Synonyms:(E)-2-(4-methoxybenzylidene)hydrazine carboxamide

Chemical Property of 4-METHOXYBENZALDEHYDE SEMICARBAZONE

Chemical Property:

• Melting Point: 203-207?°C(lit.)

Purity/Quality:

[(E)-[(4-Methoxyphenyl)methylidene]amino]urea ^*data from reagent suppliers

Safty Information:

• Safety Statements: 22-24/25

MSDS Files:

Useful:

Technology Process of 4-METHOXYBENZALDEHYDE SEMICARBAZONE

There total 10 articles about 4-METHOXYBENZALDEHYDE SEMICARBAZONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

semicarbazide hydrochloride (563-41-7) + 4-methoxy-benzaldehyde (123-11-5) → 4-methoxybenzaldehyde semicarbazone (6292-71-3,120445-53-6)

Guidance literature:

With sodium acetate; In ethanol; water; at 20 ℃;

DOI:10.1016/j.bioorg.2018.03.029

Reference yield: 95.0%

4-methoxy-benzaldehyde (123-11-5) + hydrazine carboxamide (4426-72-6,51433-48-8,57-56-7) → (E)-2-(4-methoxybenzylidene)hydrazine carboxamide (120445-53-6)

Guidance literature:

With acetic acid; In water; at 30 ℃; for 0.333333h; ultrasound irradiation;

DOI:10.1016/j.tetlet.2007.12.103

Reference yield:

4-methoxy-benzaldehyde (123-11-5) + hydrazine carboxamide (4426-72-6,51433-48-8,57-56-7) → 4-methoxybenzaldehyde semicarbazone (6292-71-3,120445-53-6)

Guidance literature:

upstream raw materials:

semicarbazide hydrochloride

4-methoxy-benzaldehyde

4-methoxybenzylidene thiosemicarbazone

dihydrogen peroxide

Downstream raw materials:

hydrazodicarboxamide

4-methoxybenzaldehydephenylhydrazone

p-methylanizole

N¹-(5-p-methoxyphenyl-1,3,4-oxadiazol-2-yl)thiourea

Refernces

• 1、 Naclerio, George A.,Abutaleb, Nader S.,Li, Daoyi,Seleem, Mohamed N.,Sintim, Herman O.. "Ultrapotent Inhibitor of Clostridioides difficile Growth, Which Suppresses Recurrence in Vivo". . p. 11934 - 11944. Retrieved 2020/11/26.
• 2、 -. "Compound containing thiosemicarbazone/semicarbazone structure and preparation method and medical application of compound". Paragraph 0278-0280. . Retrieved 2020/08/25.