(3aR,6aR)-4'-(octahydro-pyrrolo[3,4-b]pyrrol-1-yl)-biphenyl-4-carbonitrile

Base Information

Chemical Name:(3aR,6aR)-4'-(octahydro-pyrrolo[3,4-b]pyrrol-1-yl)-biphenyl-4-carbonitrile
CAS No.:948846-59-1
Molecular Formula:C₁₉H₁₉N₃
Molecular Weight:289.38
Hs Code.:

Synonyms:(3aR,6aR)-4'-(octahydro-pyrrolo[3,4-b]pyrrol-1-yl)-biphenyl-4-carbonitrile

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Chemical Property of (3aR,6aR)-4'-(octahydro-pyrrolo[3,4-b]pyrrol-1-yl)-biphenyl-4-carbonitrile

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Technology Process of (3aR,6aR)-4'-(octahydro-pyrrolo[3,4-b]pyrrol-1-yl)-biphenyl-4-carbonitrile

There total 5 articles about (3aR,6aR)-4'-(octahydro-pyrrolo[3,4-b]pyrrol-1-yl)-biphenyl-4-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 948846-58-0
(3aR,6aR)-1-(4'-cyano-biphenyl-4-yl)-octahydro-pyrrolo[3,4-b]pyrrole-5-carboxylic acid benzyl ester

: 948846-59-1
(3aR,6aR)-4'-(octahydro-pyrrolo[3,4-b]pyrrol-1-yl)-biphenyl-4-carbonitrile

Guidance literature:: With trifluoroacetic acid; for 2.5h; Reflux;
DOI:10.1021/jm900480x

Reference yield:

: 948846-57-9
(3aR,6aR)-octahydro-pyrrolo[3,4-b]pyrrole-5-carboxylic acid benzyl ester

: 948846-59-1
(3aR,6aR)-4'-(octahydro-pyrrolo[3,4-b]pyrrol-1-yl)-biphenyl-4-carbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: sodium t-butanolate / palladium diacetate; 2,2'-bis(diphenylphosphino)biphenyl / toluene / 16 h / 80 °C

2: trifluoroacetic acid / 2.5 h / Heating / reflux

With trifluoroacetic acid; sodium t-butanolate; palladium diacetate; 2,2'-bis(diphenylphosphino)biphenyl; In toluene;

Reference yield:

: 948846-56-8
(3aR,6aR)-octahydro-pyrrolo[3,4-b]pyrrole-1,5-dicarboxylic acid 5-benzyl ester 1-tert-butyl ester

: 948846-59-1
(3aR,6aR)-4'-(octahydro-pyrrolo[3,4-b]pyrrol-1-yl)-biphenyl-4-carbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: trifluoroacetic acid / dichloromethane / 2 h

2: sodium t-butanolate / palladium diacetate; 2,2'-bis(diphenylphosphino)biphenyl / toluene / 16 h / 80 °C

3: trifluoroacetic acid / 2.5 h / Heating / reflux

With trifluoroacetic acid; sodium t-butanolate; palladium diacetate; 2,2'-bis(diphenylphosphino)biphenyl; In dichloromethane; toluene;