(2R,3S)-3-(4-Methoxy-benzyloxy)-2-methyl-5-oxo-7-phenyl-heptanoic acid methyl ester

Base Information

Chemical Name:(2R,3S)-3-(4-Methoxy-benzyloxy)-2-methyl-5-oxo-7-phenyl-heptanoic acid methyl ester
CAS No.:189248-47-3
Molecular Formula:C₂₃H₂₈O₅
Molecular Weight:384.472
Hs Code.:

Synonyms:(2R,3S)-3-(4-Methoxy-benzyloxy)-2-methyl-5-oxo-7-phenyl-heptanoic acid methyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,3S)-3-(4-Methoxy-benzyloxy)-2-methyl-5-oxo-7-phenyl-heptanoic acid methyl ester

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Technology Process of (2R,3S)-3-(4-Methoxy-benzyloxy)-2-methyl-5-oxo-7-phenyl-heptanoic acid methyl ester

There total 1 articles about (2R,3S)-3-(4-Methoxy-benzyloxy)-2-methyl-5-oxo-7-phenyl-heptanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 67-56-1
methanol

: 201230-82-2
carbon monoxide

: 59417-89-9
4-phenyl-2-(trimethylsiloxy)-1-butene

: 123-11-5
4-methoxy-benzaldehyde

: 189248-47-3
(2R,3S)-3-(4-Methoxy-benzyloxy)-2-methyl-5-oxo-7-phenyl-heptanoic acid methyl ester

: 189248-48-4
(2R,3S)-3-Hydroxy-2-methyl-5-oxo-7-phenyl-heptanoic acid methyl ester

Guidance literature:: Yield given. Multistep reaction. Yields of byproduct given;
DOI:10.1021/jo9621940

Reference yield: 60.0%

: 189248-47-3
(2R,3S)-3-(4-Methoxy-benzyloxy)-2-methyl-5-oxo-7-phenyl-heptanoic acid methyl ester

: 189248-48-4
(2R,3S)-3-Hydroxy-2-methyl-5-oxo-7-phenyl-heptanoic acid methyl ester

Guidance literature:: With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane; water; for 2h; Ambient temperature;
DOI:10.1021/jo9621940

Reference yield:

: 189248-47-3
(2R,3S)-3-(4-Methoxy-benzyloxy)-2-methyl-5-oxo-7-phenyl-heptanoic acid methyl ester

: (3R,4S,6S)-4-Hydroxy-3-methyl-6-phenethyl-tetrahydro-pyran-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: 60 percent / DDQ / CH₂Cl₂; H₂O / 2 h / Ambient temperature

2: 1.) Et₃B, 2.) NaBH₄ / 1.) THF, MeOH, -78 deg C, 30 min, 2.) -78 drg C, 5 h.

3: 88 percent / p-TsOH / benzene / 8 h / Ambient temperature

With sodium tetrahydroborate; triethyl borane; toluene-4-sulfonic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane; water; benzene;
DOI:10.1021/jo9621940