2-(benzyloxy)-2-oxoethyl 3-(cyclopropylmethoxy)-4-(N-(2-(4-methylpiperazin-1-yl)ethyl)methylsulfonamido)benzoate

Base Information

Chemical Name:2-(benzyloxy)-2-oxoethyl 3-(cyclopropylmethoxy)-4-(N-(2-(4-methylpiperazin-1-yl)ethyl)methylsulfonamido)benzoate
CAS No.:1428847-47-5
Molecular Formula:C₂₈H₃₇N₃O₇S
Molecular Weight:559.684
Hs Code.:

Synonyms:2-(benzyloxy)-2-oxoethyl 3-(cyclopropylmethoxy)-4-(N-(2-(4-methylpiperazin-1-yl)ethyl)methylsulfonamido)benzoate

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Chemical Property of 2-(benzyloxy)-2-oxoethyl 3-(cyclopropylmethoxy)-4-(N-(2-(4-methylpiperazin-1-yl)ethyl)methylsulfonamido)benzoate

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Technology Process of 2-(benzyloxy)-2-oxoethyl 3-(cyclopropylmethoxy)-4-(N-(2-(4-methylpiperazin-1-yl)ethyl)methylsulfonamido)benzoate

There total 7 articles about 2-(benzyloxy)-2-oxoethyl 3-(cyclopropylmethoxy)-4-(N-(2-(4-methylpiperazin-1-yl)ethyl)methylsulfonamido)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1428847-46-4
lithium 3-(cyclopropylmethoxy)-4-(N-(2-(4-methylpiperazin-1-yl)ethyl)methylsulfonamido)benzoate

: 30379-58-9
benzyl glycolate

: 1428847-47-5
2-(benzyloxy)-2-oxoethyl 3-(cyclopropylmethoxy)-4-(N-(2-(4-methylpiperazin-1-yl)ethyl)methylsulfonamido)benzoate

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 48h;

Reference yield:

: 1239278-74-0
3-cyclopropylmethoxy-4-(N-tert-butoxycarbonyl-N-methanesulfonyl)aminobenzoic acid methyl ester

: 1428847-47-5
2-(benzyloxy)-2-oxoethyl 3-(cyclopropylmethoxy)-4-(N-(2-(4-methylpiperazin-1-yl)ethyl)methylsulfonamido)benzoate

Guidance literature:: Multi-step reaction with 6 steps

1: hydrogenchloride / dichloromethane / 72 h / 20 °C

2: potassium carbonate / acetonitrile / 12 h / 110 °C / Microwave irradiation

3: carbon tetrabromide; triphenylphosphine / dichloromethane / 2 h / 20 °C

4: potassium carbonate / acetonitrile / 3 h / 130 °C / Microwave irradiation

5: water; lithium hydroxide / tetrahydrofuran / 6 h / 20 °C

6: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 48 h / 20 °C

With hydrogenchloride; dmap; carbon tetrabromide; water; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triphenylphosphine; lithium hydroxide; In tetrahydrofuran; dichloromethane; acetonitrile;

Reference yield:

: 1239278-73-9
3-cyclopropylmethoxy-4-methanesulfonylaminobenzoic acid methyl ester

: 1428847-47-5
2-(benzyloxy)-2-oxoethyl 3-(cyclopropylmethoxy)-4-(N-(2-(4-methylpiperazin-1-yl)ethyl)methylsulfonamido)benzoate

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / acetonitrile / 12 h / 110 °C / Microwave irradiation

2: carbon tetrabromide; triphenylphosphine / dichloromethane / 2 h / 20 °C

3: potassium carbonate / acetonitrile / 3 h / 130 °C / Microwave irradiation

4: water; lithium hydroxide / tetrahydrofuran / 6 h / 20 °C

5: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 48 h / 20 °C

With dmap; carbon tetrabromide; water; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triphenylphosphine; lithium hydroxide; In tetrahydrofuran; dichloromethane; acetonitrile;