2-(4-hydroxy-2-methylphenyl)-2-oxoethyl formate

Base Information

• Chemical Name: 2-(4-hydroxy-2-methylphenyl)-2-oxoethyl formate
• CAS No.: 1265683-76-8
• Molecular Formula: C₁₀H₁₀O₄
• Molecular Weight: 194.187
• Mol file: 1265683-76-8.mol

Synonyms:2-(4-hydroxy-2-methylphenyl)-2-oxoethyl formate

Chemical Property of 2-(4-hydroxy-2-methylphenyl)-2-oxoethyl formate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-hydroxy-2-methylphenyl)-2-oxoethyl formate

There total 2 articles about 2-(4-hydroxy-2-methylphenyl)-2-oxoethyl formate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

formic acid (64-18-6) + 2-bromo-1-(4-hydroxy-2-methylphenyl)-1-ethanone (41877-16-1) → 2-(4-hydroxy-2-methylphenyl)-2-oxoethyl formate (1265683-76-8)

Guidance literature:

formic acid; With sodium hydride; In N,N-dimethyl-formamide; at 5 - 20 ℃; Inert atmosphere;

2-bromo-1-(4-hydroxy-2-methylphenyl)-1-ethanone; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1021/ol102887f

Reference yield:

4'-hydroxy-2'methylacetophenone (875-59-2) → 2-(4-hydroxy-2-methylphenyl)-2-oxoethyl formate (1265683-76-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: copper(ll) bromide / chloroform; ethyl acetate / Reflux

2.1: sodium hydride / N,N-dimethyl-formamide / 5 - 20 °C / Inert atmosphere

2.2: 20 °C

With sodium hydride; copper(ll) bromide; In chloroform; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1021/ol102887f

Reference yield: 80.0%

2-(4-hydroxy-2-methylphenyl)-2-oxoethyl formate (1265683-76-8) + methyl iodide (74-88-4) → 4-hydroxymethyl-3-methylphenol (22574-58-9) + 4-hydroxy-2-methylphenylacetic acid methyl ester (114474-04-3)

Guidance literature:

2-(4-hydroxy-2-methylphenyl)-2-oxoethyl formate; In water; acetonitrile; Irradiation;

methyl iodide; With potassium carbonate; In acetonitrile; Reflux;

DOI:10.1021/ol102887f

upstream raw materials:

formic acid

2-bromo-1-(4-hydroxy-2-methylphenyl)-1-ethanone

4'-hydroxy-2'methylacetophenone

Downstream raw materials:

5-benzyloxy-1-indanone

4-hydroxymethyl-3-methylphenol

4-hydroxy-2-methylphenylacetic acid methyl ester