3-(Triphenyl-lambda~5~-phosphanylidene)butan-2-one

Base Information

• Chemical Name: 3-(Triphenyl-lambda~5~-phosphanylidene)butan-2-one
• CAS No.: 26487-92-3
• Molecular Formula: C22H21 O P
• Molecular Weight: 332.382
• NSC Number: 180957
• DSSTox Substance ID: DTXSID90306886
• Nikkaji Number: J500.738K,J329.170G
• Wikidata: Q82054192
• Mol file: 26487-92-3.mol

Synonyms:26487-92-3;NSC180957;SCHEMBL3995747;DTXSID90306886;JDYOMWDXAAPCEE-UHFFFAOYSA-N;3-triphenylphosphoranylidenebutan-2-one;NSC-180957;3-(Triphenyl-lambda~5~-phosphanylidene)butan-2-one

Chemical Property of 3-(Triphenyl-lambda~5~-phosphanylidene)butan-2-one

Chemical Property:

• Vapor Pressure: 1.48E-09mmHg at 25°C
• Boiling Point: 484.9°C at 760 mmHg
• Flash Point: 247°C
• Density: 1.13g/cm³
• XLogP3: 3.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 4
• Exact Mass: 332.133002287
• Heavy Atom Count: 24
• Complexity: 422

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)C(=P(C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3)C

Technology Process of 3-(Triphenyl-lambda~5~-phosphanylidene)butan-2-one

There total 14 articles about 3-(Triphenyl-lambda~5~-phosphanylidene)butan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

triphenylphosphine (603-35-0) + 3-bromo-butanone (814-75-5) → 3-(triphenylphosphoranylidene)butan-2-one (26487-92-3)

Guidance literature:

In acetonitrile; at 70 ℃; for 9h;

DOI:10.3390/molecules25194527

Reference yield: 79.0%

(1-methyl-2-oxopropyl)triphenylphosphonium bromide (7237-40-3) → 3-(triphenylphosphoranylidene)butan-2-one (26487-92-3)

Guidance literature:

With sodium hydroxide; In methanol; at 20 ℃; for 2h; Inert atmosphere;

DOI:10.1021/acs.orglett.8b04129

Reference yield: 72.0%

acetic anhydride (108-24-7) + 1-trimethylsilyl ethylene triphenylphosphorane (82294-33-5) → Hexamethyldisiloxane (107-46-0) + 3-(triphenylphosphoranylidene)butan-2-one (26487-92-3)

Guidance literature:

In tetrahydrofuran; Heating;

DOI:10.1055/s-1992-26227

upstream raw materials:

(1-methyl-2-oxopropyl)triphenylphosphonium bromide

3-chloro-2-butanone

acetic anhydride

1-trimethylsilyl ethylene triphenylphosphorane

Downstream raw materials:

3,4-diacetyl-4-methyl-5,5,5-triphenyl-4,5-dihydro-5λ⁵-[1,2,5]oxazaphosphole

pseudoionone

(E)-3-Methyl-1-phenyl-pent-2-ene-1,4-dione

3-methyl-4-(4'-nitrophenyl)-3-buten-2-one