hydroxy(4-(3-methyl-4-oxothiazolidin-2-ylideneamino)phenyl)acetic acid ethyl ester

Base Information

• Chemical Name: hydroxy(4-(3-methyl-4-oxothiazolidin-2-ylideneamino)phenyl)acetic acid ethyl ester
• CAS No.: 1186634-12-7
• Molecular Formula: C₁₄H₁₆N₂O₄S
• Molecular Weight: 308.358
• Mol file: 1186634-12-7.mol

Synonyms:hydroxy(4-(3-methyl-4-oxothiazolidin-2-ylideneamino)phenyl)acetic acid ethyl ester

Chemical Property of hydroxy(4-(3-methyl-4-oxothiazolidin-2-ylideneamino)phenyl)acetic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of hydroxy(4-(3-methyl-4-oxothiazolidin-2-ylideneamino)phenyl)acetic acid ethyl ester

There total 5 articles about hydroxy(4-(3-methyl-4-oxothiazolidin-2-ylideneamino)phenyl)acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.7%

hydroxy(4-(3-methylthioureido)phenyl)acetic acid ethyl ester (1186634-11-6) + ethyl bromoacetate (105-36-2) → hydroxy(4-(3-methyl-4-oxothiazolidin-2-ylideneamino)phenyl)acetic acid ethyl ester (1186634-12-7)

Guidance literature:

With triethylamine; In ethanol; for 5h; Reflux;

Reference yield:

p-nitromandelonitrile (121986-07-0,137766-69-9,13312-80-6) → hydroxy(4-(3-methyl-4-oxothiazolidin-2-ylideneamino)phenyl)acetic acid ethyl ester (1186634-12-7)

Guidance literature:

Multi-step reaction with 4 steps

1.1: hydrogenchloride / water; acetic acid / 4 h / 100 °C

1.2: 4 h / 80 - 85 °C

2.1: hydrogen / palladium on activated charcoal / methanol / 4 h

3.1: ethanol / 6 h / Reflux

4.1: triethylamine / ethanol / 5 h / Reflux

With hydrogenchloride; hydrogen; triethylamine; palladium on activated charcoal; In methanol; ethanol; water; acetic acid;

Reference yield:

4-nitro-mandelic acid-ethyl ester (13312-87-3) → hydroxy(4-(3-methyl-4-oxothiazolidin-2-ylideneamino)phenyl)acetic acid ethyl ester (1186634-12-7)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogen / palladium on activated charcoal / methanol / 4 h

2: ethanol / 6 h / Reflux

3: triethylamine / ethanol / 5 h / Reflux

With hydrogen; triethylamine; palladium on activated charcoal; In methanol; ethanol;

upstream raw materials:

hydroxy(4-(3-methylthioureido)phenyl)acetic acid ethyl ester

ethyl bromoacetate

p-nitromandelonitrile

4-nitro-mandelic acid-ethyl ester

Downstream raw materials:

(4-(5-(1-(4-(4-cyclohexylbenzyloxy)phenyl)methylidene)-3-methyl-4-oxothiazolidin-2-ylideneamino)phenyl)hydroxyacetic acid ethyl ester

fluoro(4-(3-methyl-4-oxothiazolidin-2-ylideneamino)phenyl)acetic acid ethyl ester

(4-(5-(1-(4-(4-cyclohexylbenzyloxy)phenyl)methylidene)-3-methyl-4-oxothiazolidin-2-ylideneamino)phenyl)hydroxyacetic acid

(4-(5-(1-(4-(4-cyclohexylbenzyloxy)phenyl)methylidene)-3-methyl-4-oxothiazolidin-2-ylideneamino)phenyl)fluoroacetic acid ethyl ester