2-Propen-1-one,1-(5-hydroxy-7-methoxy-2,2-dimethyl-2H-1-benzopyran-6-yl)-3-(4-methoxyphenyl)-,(2E)-

Base Information

Chemical Name:2-Propen-1-one,1-(5-hydroxy-7-methoxy-2,2-dimethyl-2H-1-benzopyran-6-yl)-3-(4-methoxyphenyl)-,(2E)-
CAS No.:143885-75-0
Molecular Formula:C22H22 O5
Molecular Weight:366.414
Hs Code.:

Synonyms:2-Propen-1-one,1-(5-hydroxy-7-methoxy-2,2-dimethyl-2H-1-benzopyran-6-yl)-3-(4-methoxyphenyl)-,(E)-; Glychalcone A

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-Propen-1-one,1-(5-hydroxy-7-methoxy-2,2-dimethyl-2H-1-benzopyran-6-yl)-3-(4-methoxyphenyl)-,(2E)-

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2-Propen-1-one,1-(5-hydroxy-7-methoxy-2,2-dimethyl-2H-1-benzopyran-6-yl)-3-(4-methoxyphenyl)-,(2E)-

There total 15 articles about 2-Propen-1-one,1-(5-hydroxy-7-methoxy-2,2-dimethyl-2H-1-benzopyran-6-yl)-3-(4-methoxyphenyl)-,(2E)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 25983-76-0
isoevodionol

: 123-11-5
4-methoxy-benzaldehyde

: 143885-75-0
(2E)-1-(5-hydroxy-7-methoxy-2,2-dimethyl-2H-chromen-6-yl)-3-(4-methoxyphenyl)prop-2-en-1-one

Guidance literature:: With potassium hydroxide; In ethanol; water; at 20 ℃; for 8h;
DOI:10.1002/jccs.200700119

Reference yield:

: 3602-54-8
4,6-dihydroxy-2-methoxyacetophenone

: 143885-75-0
(2E)-1-(5-hydroxy-7-methoxy-2,2-dimethyl-2H-chromen-6-yl)-3-(4-methoxyphenyl)prop-2-en-1-one

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / ethylenediamine diacetate / toluene / 12 h / Heating

2: 85 percent / potassium hydroxide / ethanol / 48 h / 20 °C

With potassium hydroxide; ethylenediamine diacetic acid; In ethanol; toluene;
DOI:10.3390/12071420

Reference yield:

: 65490-09-7
2'-hydroxy-4',6'-bis(methoxymethoxy)acetophenone

: 143885-75-0
(2E)-1-(5-hydroxy-7-methoxy-2,2-dimethyl-2H-chromen-6-yl)-3-(4-methoxyphenyl)prop-2-en-1-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: K₂CO₃ / acetone / 4 h / Heating

1.2: 91 percent / SiO₂ / flash column chromatography

2.1: 90 percent / N,N-dimethylaniline / 4.5 h / Heating

3.1: 86 percent / K₂CO₃ / acetone / 0.5 h / Heating

4.1: 88 percent / 3N HCl / methanol / 0.25 h / Heating

5.1: 81 percent / DDQ / benzene; dioxane / 4.5 h / Heating

6.1: 81 percent / KOH / ethanol; H₂O / 36 h / 25 °C

With hydrogenchloride; potassium hydroxide; potassium carbonate; N,N-dimethyl-aniline; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In 1,4-dioxane; methanol; ethanol; water; acetone; benzene; 2.1: Claisen rearrangement;
DOI:10.1081/SCC-120003156