(-)-Hydroxyzine

Base Information

• Chemical Name: (-)-Hydroxyzine
• CAS No.: 147152-23-6
• Molecular Formula: C₂₁H₂₇ClN₂O₂
• Molecular Weight: 374.911
• Mol file: 147152-23-6.mol

Synonyms:(-)-Hydroxyzine

Chemical Property of (-)-Hydroxyzine

Chemical Property:

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (-)-Hydroxyzine

There total 4 articles about (-)-Hydroxyzine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

p-chlorobenzhydrylamine (28022-43-7) + 2,2'-iminobis[ethanol] (111-42-2) + diethylene glycol (111-46-6) → hydroxizine (68-88-2,147152-22-5,147152-23-6,189298-46-2)

Guidance literature:

p-chlorobenzhydrylamine; 2,2'-iminobis[ethanol]; With iridium graphene nanostructured catalyst; at 110 ℃; Schlenk technique; Inert atmosphere; Green chemistry;

diethylene glycol; at 110 ℃; Inert atmosphere; Schlenk technique; Green chemistry;

DOI:10.1039/d1ra09052f

Reference yield:

oxirane (75-21-8,99932-75-9) → hydroxizine (68-88-2,147152-22-5,147152-23-6,189298-46-2)

Guidance literature:

With toluene; at 170 ℃;

Reference yield:

→ hydroxizine (68-88-2,147152-22-5,147152-23-6,189298-46-2)

Guidance literature:

With thionyl chloride; benzene; anschl. Erwaermen mit der Mononatrium-Verbindung des Aethylenglykols auf 100grad;

upstream raw materials:

oxirane

p-chlorobenzhydrylamine

2,2'-iminobis[ethanol]

diethylene glycol

Downstream raw materials:

C₂₁H₂₅ClN₂O₂

Refernces