1-ETHYL-1H-INDOLE-3-CARBALDEHYDE

Base Information

• Chemical Name: 1-ETHYL-1H-INDOLE-3-CARBALDEHYDE
• CAS No.: 58494-59-0
• Molecular Formula: C11H11NO
• Molecular Weight: 173.214
• Hs Code.: 2933990090
• Mol file: 58494-59-0.mol

Synonyms:TIMTEC-BB SBB010556;AKOS BC-1646;1-ETHYL-1H-INDOLE-3-CARBALDEHYDE;CHEMBRDG-BB 4002644;ASINEX-REAG BAS 02891397;ASISCHEM R36078

Chemical Property of 1-ETHYL-1H-INDOLE-3-CARBALDEHYDE

Chemical Property:

• Vapor Pressure: 0.000199mmHg at 25°C
• Refractive Index: 1.574
• Boiling Point: 327.7°C at 760 mmHg
• Flash Point: 152°C
• PSA: 22.00000
• Density: 1.08g/cm³
• LogP: 2.47370
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

1-Ethyl-1H-indole-3-carbaldehyde ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi,Xn
• Statements: 22-36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1-Ethyl-1H-indole-3-carbaldehyde is used to build Inhibitors of PEX14-PEX5 Protein-Protein Interaction with trypanocidal activity.

Technology Process of 1-ETHYL-1H-INDOLE-3-CARBALDEHYDE

There total 27 articles about 1-ETHYL-1H-INDOLE-3-CARBALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

N-Ethylindole (10604-59-8) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → N-ethyl-3-formylindole (58494-59-0)

Guidance literature:

With trichlorophosphate; In 1,2-dichloro-ethane; at 35 - 100 ℃; for 7h;

DOI:10.1039/c5ra12969a

Reference yield: 96.0%

Indole-3-carboxaldehyde (487-89-8,1228547-52-1) + diethyl sulfate (64-67-5) → N-ethyl-3-formylindole (58494-59-0)

Guidance literature:

With sodium hydroxide; In water; dimethyl sulfoxide; at 30 ℃; for 1.5h;

DOI:10.1002/jhet.2382

Reference yield: 95.0%

Indole-3-carboxaldehyde (487-89-8,1228547-52-1) + ethyl bromide (74-96-4) → N-ethyl-3-formylindole (58494-59-0)

Guidance literature:

Indole-3-carboxaldehyde; With sodium hydride; In acetonitrile; for 0.166667h; Inert atmosphere;

ethyl bromide; In acetonitrile; at 20 ℃; for 2h; Inert atmosphere;

DOI:10.1007/s10895-016-1901-5

upstream raw materials:

Indole-3-carboxaldehyde

ethyl bromide

ethyl iodide

carbon monoxide

Downstream raw materials:

1-ethyl-3-[(E)-2-phenylethenyl]-1H-indole

Refernces

• 1、 Geng, Rong-Xia,Kumar, Kannekanti Vijaya,Li, Shuo,Yang, Xun-Cai,Zhang, Peng-Li,Zhou, Cheng-He. "Discovery of unique thiazolidinone-conjugated coumarins as novel broad spectrum antibacterial agents". . . Retrieved 2022/02/16.
• 2、 Mashayekhi, Vida,Haj Mohammad Ebrahim Tehrani, Kamaleddin,Azerang, Parisa,Sardari, Soroush,Kobarfard, Farzad. "Synthesis, antimycobacterial and anticancer activity of novel indole-based thiosemicarbazones". . . Retrieved 2021/09/08.