4-METHOXY-N-METHYLBENZAMIDE

Base Information

• Chemical Name: 4-METHOXY-N-METHYLBENZAMIDE
• CAS No.: 3400-22-4
• Molecular Formula: C9H11NO2
• Molecular Weight: 165.192
• Hs Code.: 2924299090
• Mol file: 3400-22-4.mol

Synonyms:p-Anisamide,N-methyl- (6CI,7CI,8CI);4-Methoxy-N-methylbenzamide;N-Methyl-4-methoxybenzamide;N-Methyl-p-methoxybenzamide;NSC 404038;p-Methoxy-N-methylbenzamide;

Chemical Property of 4-METHOXY-N-METHYLBENZAMIDE

Chemical Property:

• Vapor Pressure: 0.000274mmHg at 25°C
• Refractive Index: 1.517
• Boiling Point: 322.7 °C at 760 mmHg
• Flash Point: 149 °C
• PSA: 38.33000
• Density: 1.074 g/cm³
• LogP: 1.44570
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

4-methoxy-n-methylbenzamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-METHOXY-N-METHYLBENZAMIDE

There total 48 articles about 4-METHOXY-N-METHYLBENZAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

methanol (67-56-1) + 4-methoxybenzonitrile (874-90-8) → 4-methoxy-N-methylbenzamide (3400-22-4)

Guidance literature:

With tris(2-diphenylphosphinoethyl)phosphine; potassium tert-butylate; water; caesium carbonate; cobalt(II) bromide; In m-xylene; at 140 ℃; for 36h; Green chemistry;

DOI:10.1021/acscatal.9b03916

Reference yield: 96.0%

4,N-dimethoxy-N-methylbenzamide (52898-49-4) → 4-methoxy-N-methylbenzamide (3400-22-4)

Guidance literature:

With sodium metal trapped in the nanoscale pores of silica gel; In tetrahydrofuran; at 20 ℃; for 2h; Reagent/catalyst; Glovebox; Sealed tube; Inert atmosphere;

DOI:10.1016/j.tetlet.2015.09.099

Reference yield: 90.0%

dicobalt octacarbonyl (15226-74-1,61091-28-9,61117-58-6) + methylamine (74-89-5) → 4-methoxy-N-methylbenzamide (3400-22-4)

Guidance literature:

With dmap; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 90 ℃; for 0.333333h; Sealed tube; Microwave irradiation;

DOI:10.1016/j.tetlet.2013.12.062

upstream raw materials:

4-methoxy-benzoyl chloride

methylamine

N-Methyl-O-p-nitrophenylsulphonylhydroxylamine

4-methoxy-benzaldehyde

Downstream raw materials:

N-methyl-p-methoxythiobenzamide

4-methoxy-N-methylbenzylamine

5-(4-chloro-phenyl)-2-(4-methoxy-phenyl)-3-methyl-4,6-dioxo-5,6-dihydro-4H-[1,3]oxazinium betaine

2-(4-methoxy-phenyl)-3,5-dimethyl-4,6-dioxo-5,6-dihydro-4H-[1,3]oxazinium betaine