METHYL 2-CHLORO-5-HYDROXYBENZOATE

Base Information

• Chemical Name: METHYL 2-CHLORO-5-HYDROXYBENZOATE
• CAS No.: 247092-10-0
• Molecular Formula: C8H7 Cl O3
• Molecular Weight: 186.595
• Hs Code.: 2918290000
• Mol file: 247092-10-0.mol

Synonyms:2-Chloro-5-hydroxybenzoicacid methyl ester; Methyl 2-chloro-5-hydroxybenzoate

Chemical Property of METHYL 2-CHLORO-5-HYDROXYBENZOATE

Chemical Property:

• Vapor Pressure: 0.000173mmHg at 25°C
• Boiling Point: 320.1oC at 760 mmHg
• PKA: 8.70±0.18(Predicted)
• Flash Point: 147.4oC
• PSA: 46.53000
• Density: 1.354g/cm3
• LogP: 1.83220
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

Methyl2-chloro-5-hydroxybenzoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of METHYL 2-CHLORO-5-HYDROXYBENZOATE

There total 6 articles about METHYL 2-CHLORO-5-HYDROXYBENZOATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

methanol (67-56-1) + 2-chloro-5-hydroxybenzoic acid (56961-30-9) → 2-chloro-5-hydroxy-benzoic acid methyl ester (247092-10-0)

Guidance literature:

With thionyl chloride; at 20 ℃; for 3h;

DOI:10.1016/j.ejmech.2013.11.031

Reference yield: 57.0%

methyl 3-hydroxybenzoate (19438-10-9) → 2-chloro-5-hydroxy-benzoic acid methyl ester (247092-10-0) + methyl 2-chloro-3-hydroxybenzoate (1125632-11-2)

Guidance literature:

With N-chloro-succinimide; C₂₄H₂₀F₁₂N₄OS; In chloroform-d1; at 20 ℃; for 20h; regioselective reaction;

DOI:10.1021/acs.orglett.6b02650

Reference yield: 57.0%

methyl 3-hydroxybenzoate (19438-10-9) → 2-chloro-5-hydroxy-benzoic acid methyl ester (247092-10-0) + methyl 2-chloro-3-hydroxybenzoate (1125632-11-2) + 4-Chloro-3-hydroxy-benzoic acid methyl ester (166272-81-7)

Guidance literature:

With N-chloro-succinimide; (R)-[1,1′-binaphthalene]-2,2′-diylbis-(diphenylphosphine sulfide); In chloroform-d1; at 20 ℃; for 1h; regioselective reaction;

DOI:10.1021/acs.orglett.6b02650

upstream raw materials:

methanol

2-chloro-5-hydroxybenzoic acid

2-chloro-5-aminobenzoic acid

methyl 3-hydroxybenzoate

Downstream raw materials:

2-chloro-5-hydroxybenzamide

(S)-tert-butyl 3-(3-carbamoyl-4-chlorophenoxy)pyrrolidine-1-carboxylate

2-chloro-5-dimethylthiocarbamoyloxy-benzoic acid methyl ester

2-chloro-5-mercapto-benzoic acid