Ethyl 2-(4-methoxyphenyl)thiazole-4-carboxylate

Base Information

• Chemical Name: Ethyl 2-(4-methoxyphenyl)thiazole-4-carboxylate
• CAS No.: 57677-79-9
• Molecular Formula: C13H13 N O3 S
• Molecular Weight: 263.317
• Hs Code.: 2934100090
• DSSTox Substance ID: DTXSID00439331
• Nikkaji Number: J2.996.799G
• Wikidata: Q82255251
• Mol file: 57677-79-9.mol

Synonyms:57677-79-9;Ethyl 2-(4-methoxyphenyl)thiazole-4-carboxylate;Ethyl 2-(4-methoxyphenyl)-1,3-thiazole-4-carboxylate;2-(4-Methoxy-phenyl)-thiazole-4-carboxylic acid ethyl ester;2-(4-Methoxyphenyl)thiazole-4-carboxylic acid ethyl ester;Ethyl2-(4-methoxyphenyl)thiazole-4-carboxylate;SCHEMBL201788;DTXSID00439331;IZEUWGPRBNUAFE-UHFFFAOYSA-N;MFCD06738343;AKOS000360045;AB26945;AM20060981;CS-0151683;FT-0679988;A831548;10Z-0718;Ethyl 2-(4-methoxyphenyl)thiazole-4-carboxylate, AldrichCPR

Chemical Property of Ethyl 2-(4-methoxyphenyl)thiazole-4-carboxylate

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 94-96oC
• Boiling Point: 399.783oC at 760 mmHg
• Flash Point: 195.582oC
• PSA: 76.66000
• Density: 1.22g/cm3
• LogP: 2.99540
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 3.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 5
• Exact Mass: 263.06161445
• Heavy Atom Count: 18
• Complexity: 279

Purity/Quality:

98%Min ^*data from raw suppliers

Ethyl 2-(4-methoxyphenyl)thiazole-4-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(=O)C1=CSC(=N1)C2=CC=C(C=C2)OC

Technology Process of Ethyl 2-(4-methoxyphenyl)thiazole-4-carboxylate

There total 18 articles about Ethyl 2-(4-methoxyphenyl)thiazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

ethyl 2-(4-hydroxyphenyl)thiazole-4-carboxylate + methyl iodide (74-88-4) → ethyl 2-(4-methoxyphenyl)thiazole-4-carboxylate (57677-79-9)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 40 ℃; for 8h;

DOI:10.3184/174751918X15314837408346

Reference yield: 89.0%

p-methoxythiobenzamide (2362-64-3) + ethyl diazopyruvate (14214-10-9) → ethyl 2-(4-methoxyphenyl)thiazole-4-carboxylate (57677-79-9)

Guidance literature:

With boron trifluoride diethyl etherate; In 1,2-dimethoxyethane; for 3h; Heating;

Reference yield: 85.0%

L-cysteine ethyl ester hydrochloride (868-59-7) + 4-methoxy-benzaldehyde (123-11-5) → ethyl 2-(4-methoxyphenyl)thiazole-4-carboxylate (57677-79-9)

Guidance literature:

With tert.-butylhydroperoxide; iodine; potassium carbonate; In 1,4-dioxane; at 70 ℃; for 12h; Schlenk technique; Molecular sieve; Inert atmosphere;

DOI:10.1039/c8ob02826e

upstream raw materials:

(4R) ethyl 2-(4-methoxyphenyl)thiazolidine-4-carboxylate

p-methoxythiobenzamide

ethyl diazopyruvate

L-cystein ethyl ester

Downstream raw materials:

2-(4-methoxyphenyl)thiazole-4-carboxylic acid

2-chloro-1-[2-(4-methoxy-phenyl)-thiazol-4-yl]-ethanone

2-diazo-1-[2-(4-methoxy-phenyl)-thiazol-4-yl]-ethanone

2-(4-methoxy-phenyl)-thiazole-4-carboxylic acid hydrochloride