(S)-Methyl 2,3-dihydroxypropanoate

Base Information

• Chemical Name: (S)-Methyl 2,3-dihydroxypropanoate
• CAS No.: 10303-88-5
• Molecular Formula: C4H8O4
• Molecular Weight: 120.105
• Hs Code.: 2918199090
• Mol file: 10303-88-5.mol

Synonyms:methyl (2S)-2,3-dihydroxypropanoate

Chemical Property of (S)-Methyl 2,3-dihydroxypropanoate

Chemical Property:

• Vapor Pressure: 0.006mmHg at 25°C
• Refractive Index: 1.456
• Boiling Point: 241.499 °C at 760 mmHg
• PKA: 12.26±0.20(Predicted)
• Flash Point: 103.748 °C
• PSA: 66.76000
• Density: 1.285 g/cm³
• LogP: -1.48740
• Storage Temp.: Sealed in dry,Store in freezer, under -20°C

Purity/Quality:

97% ^*data from raw suppliers

(S)-Methyl2,3-dihydroxypropanoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-Methyl 2,3-dihydroxypropanoate

There total 14 articles about (S)-Methyl 2,3-dihydroxypropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methyl (4S)-2,2-dimethyl-1,3-dioxolane-4-carboxylate (60456-21-5) → methyl L-glycerate (10303-88-5,15909-76-9)

Guidance literature:

With hydrogenchloride; methanol; for 1h; Ambient temperature;

DOI:10.1016/S0040-4039(00)95704-6

Reference yield: 94.0%

methanol (67-56-1) + (S)-glyceric acid (473-81-4,600-19-1,6000-40-4,28305-26-2,118916-26-0) → methyl L-glycerate (10303-88-5,15909-76-9)

Guidance literature:

With hydrogenchloride;

DOI:10.1016/j.tetlet.2007.02.027

Reference yield: 93.0%

L-serin (56-45-1,83245-15-2) + trimethyl orthoformate (149-73-5) → methyl L-glycerate (10303-88-5,15909-76-9)

Guidance literature:

L-serin; With sulfuric acid; sodium nitrite;

trimethyl orthoformate; With sulfuric acid; In methanol;

DOI:10.1248/cpb.52.163

upstream raw materials:

methanol

(S)-glyceric acid

L-serin

methyl (4S)-2,2-dimethyl-1,3-dioxolane-4-carboxylate

Downstream raw materials:

methyl (2S)-2-hydroxy-3-(triphenylmethoxy)propanoate

methyl (4S)-2,2-dimethyl-1,3-dioxolane-4-carboxylate

(2R,4S)-((Z)-2-Heptadec-8-enyl)-[1,3]dioxolane-4-carboxylic acid methyl ester

methyl 3-(p-toluenesulfonyl)-L-glycerate