METHYL 2-BROMO-4,5-DIFLUOROBENZOATE

Base Information

• Chemical Name: METHYL 2-BROMO-4,5-DIFLUOROBENZOATE
• CAS No.: 878207-28-4
• Molecular Formula: C8H5BrF2O2
• Molecular Weight: 251.027
• Hs Code.: 2916399090
• Mol file: 878207-28-4.mol

Synonyms:benzoic acid, 2-bromo-4,5-difluoro-, methyl ester;Methyl 2-Bromo-4,5-Difluorobenzoate;LogP

Chemical Property of METHYL 2-BROMO-4,5-DIFLUOROBENZOATE

Chemical Property:

• Vapor Pressure: 0.0229mmHg at 25°C
• Refractive Index: 1.513
• Boiling Point: 249.5°C at 760 mmHg
• Flash Point: 104.7°C
• PSA: 26.30000
• Density: 1.652g/cm³
• LogP: 2.51390
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

Methyl2-bromo-4,5-difluorobenzoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of METHYL 2-BROMO-4,5-DIFLUOROBENZOATE

There total 8 articles about METHYL 2-BROMO-4,5-DIFLUOROBENZOATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.6%

2-bromo-4,5-difluorobenzoic acid (64695-84-7) + methyl iodide (74-88-4) → 2-bromo-4,5-difluorobenzoic acid methyl ester (878207-28-4)

Guidance literature:

With caesium carbonate; In acetone; for 1h; Reflux;

Reference yield: 94.0%

2-bromo-4,5-difluorobenzoic acid (64695-84-7) + diazomethyl-trimethyl-silane (18107-18-1) → 2-bromo-4,5-difluorobenzoic acid methyl ester (878207-28-4)

Guidance literature:

In methanol; dichloromethane; at 20 ℃; for 1h;

Reference yield: 93.0%

methanol (67-56-1) + 2-bromo-4,5-difluorobenzoic acid (64695-84-7) → 2-bromo-4,5-difluorobenzoic acid methyl ester (878207-28-4)

Guidance literature:

With acetyl chloride; at 65 ℃; Inert atmosphere;

DOI:10.1128/AAC.00670-16

upstream raw materials:

4,5-Difluoro-phthalic acid 1-methyl ester 2-(2-thioxo-2H-pyridin-1-yl) ester

4,5-dichlorophthalic anhydride

4,5-difluorophthalic anhydride

2-Chlorocarbonyl-4,5-difluoro-benzoic acid methyl ester

Downstream raw materials:

methyl 4-(benzylamino)-2-bromo-5-fluorobenzoate

methyl 4-(5-(benzyloxy)-1H-indol-1-yl)-2-bromo-5-fluorobenzoate

6-(5-(benzyloxy)-1H-indol-1-yl)-5-fluorobenzo[c][1,2]oxaborol-1(3H)-ol

(4-(5-(benzyloxy)-1H-indol-1-yl)-2-bromo-5-fluorophenyl)methanol

Refernces

• 1、 -. "NOVEL UREAS HAVING ANDROGEN RECEPTOR DEGRADATION ACTIVITY AND USES THEREOF". Paragraph 0209-0210. . Retrieved 2021/04/02.
• 2、 -. "Substituted quinoline-8-carbonitrile derivatives having androgen receptor degradation activity and uses thereof". Page/Page column 103-104. . Retrieved 2020/11/23.