(R)-1-[4-(trifluoromethyl)phenyl]ethan-1-ol

Base Information

• Chemical Name: (R)-1-[4-(trifluoromethyl)phenyl]ethan-1-ol
• CAS No.: 68120-43-4
• Molecular Formula: C₉H₉F₃O
• Molecular Weight: 190.165
• Mol file: 68120-43-4.mol

Synonyms:

Chemical Property of (R)-1-[4-(trifluoromethyl)phenyl]ethan-1-ol

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-1-[4-(trifluoromethyl)phenyl]ethan-1-ol

There total 52 articles about (R)-1-[4-(trifluoromethyl)phenyl]ethan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-(4-trifluoromethylphenyl)ethanone (709-63-7) → (R)-1-[4-(trifluoromethyl)phenyl]ethan-1-ol (1737-26-4,68120-43-4,99493-93-3,76155-79-8)

Guidance literature:

With (S,S)-RuCl₂(2,2'-bis(di-3,5-xylylphosphino)-1,1'-binaphthyl)(1,1-dianisyl-2-isopropyl-1,2-ethylenediamine); potassium tert-butylate; hydrogen; In isopropyl alcohol; at 26 - 30 ℃; for 20h; under 7600 Torr;

DOI:10.1021/ja983257u

Reference yield: 98.0%

Isopropenyl acetate (108-22-5) + 1-(4-trifluorophenyl)ethanol (1737-26-4) → (S)-1-(4-trifluoromethylphenyl)ethanol (99493-93-3) + (R)-1-[4-(trifluoromethyl)phenyl]ethan-1-ol (1737-26-4,68120-43-4,99493-93-3,76155-79-8) + (R)-1-acetoxy-1-(4-trifluoromethylphenyl)ethane (172424-27-0)

Guidance literature:

With Candida antarctica lipase B; dicarbonyl(chloro)(η⁵-pentaphenylcyclopentadienyl)ruthenium(II); potassium tert-butylate; sodium carbonate; In tetrahydrofuran; toluene; at 20 ℃; for 24h;

DOI:10.1021/ja051576x

Reference yield: 98.0%

4-Trifluoromethylbenzaldehyde (455-19-6) + dimethyl zinc(II) (544-97-8) → (R)-1-[4-(trifluoromethyl)phenyl]ethan-1-ol (1737-26-4,68120-43-4,99493-93-3,76155-79-8)

Guidance literature:

4-Trifluoromethylbenzaldehyde; dimethyl zinc(II); With (2R,3S,3aS,4aR,6R,8aS)-2-isopropyl-6,9,9-trimethyl-3-phenyldecahydro-4aH-pyrrolo[2,1-b][1,3]benzoxazin-3-ol; In hexane; toluene; at -20 - 20 ℃; for 30h; Inert atmosphere;

With ammonium chloride; In hexane; water; toluene; optical yield given as %ee; enantioselective reaction; Inert atmosphere;

DOI:10.1055/s-0031-1289742

upstream raw materials:

4-Trifluoromethylbenzaldehyde

dimethyl zinc(II)

1-(4-trifluoromethylphenyl)ethanone

1-trifluoromethyl-4-vinyl-benzene

Downstream raw materials:

[(1R)-1-[4-(trifluoromethyl)phenyl]ethyl] methanesulfonate

triethyl (2S)-2-[4-(trifluoromethyl)phenyl]propane-1,1,1-tricarboxylate

(S)-2-Methyl-1-[(S)-1-(4-trifluoromethyl-phenyl)-ethyl]-piperazine

(S)-3-Methyl-4-[(R)-1-(4-trifluoromethyl-phenyl)-ethyl]-piperazine-1-carboxylic acid tert-butyl ester