4-[5-(3-methyl-5-{[4-(piperidin-4-yloxy)pyrimidin-2-yl]amino}phenyl)-1,3-thiazol-2-yl]-1,4-diazepan-2-one trifluoroacetate

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Chemical Name:4-[5-(3-methyl-5-{[4-(piperidin-4-yloxy)pyrimidin-2-yl]amino}phenyl)-1,3-thiazol-2-yl]-1,4-diazepan-2-one trifluoroacetate
CAS No.:1312572-48-7
Molecular Formula:C₂HF₃O₂*C₂₄H₂₉N₇O₂S
Molecular Weight:593.63
Hs Code.:

Synonyms:

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Chemical Property of 4-[5-(3-methyl-5-{[4-(piperidin-4-yloxy)pyrimidin-2-yl]amino}phenyl)-1,3-thiazol-2-yl]-1,4-diazepan-2-one trifluoroacetate

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Technology Process of 4-[5-(3-methyl-5-{[4-(piperidin-4-yloxy)pyrimidin-2-yl]amino}phenyl)-1,3-thiazol-2-yl]-1,4-diazepan-2-one trifluoroacetate

There total 9 articles about 4-[5-(3-methyl-5-{[4-(piperidin-4-yloxy)pyrimidin-2-yl]amino}phenyl)-1,3-thiazol-2-yl]-1,4-diazepan-2-one trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 109384-19-2
t-butyl 4-hydroxy piperidine-1-carboxylate

: 1312572-48-7
4-[5-(3-methyl-5-{[4-(piperidin-4-yloxy)pyrimidin-2-yl]amino}phenyl)-1,3-thiazol-2-yl]-1,4-diazepan-2-one trifluoroacetate

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate / N,N-dimethyl-formamide / 70 - 80 °C

2: caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / palladium diacetate / 1,4-dioxane / 100 °C / Inert atmosphere

3: dichloromethane / 1 h

With caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; palladium diacetate; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 74586-53-1
3-bromo-5-methylaniline

: 1312572-48-7
4-[5-(3-methyl-5-{[4-(piperidin-4-yloxy)pyrimidin-2-yl]amino}phenyl)-1,3-thiazol-2-yl]-1,4-diazepan-2-one trifluoroacetate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium acetate; XPhos / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 4 h / 20 - 80 °C / Inert atmosphere

2: caesium carbonate; XPhos / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 16 h / 90 °C / Inert atmosphere; sealed flask

3: caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / palladium diacetate / 1,4-dioxane / 100 °C / Inert atmosphere

4: dichloromethane / 1 h

With potassium acetate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium diacetate; In 1,4-dioxane; dichloromethane;

Reference yield:

: 44981-94-4
N-cyanoethyl glycine ethyl ester

: 1312572-48-7
4-[5-(3-methyl-5-{[4-(piperidin-4-yloxy)pyrimidin-2-yl]amino}phenyl)-1,3-thiazol-2-yl]-1,4-diazepan-2-one trifluoroacetate

Guidance literature:: Multi-step reaction with 7 steps

1.1: chloroform / 20 °C

2.1: hydrogen; ammonia / Rany-Ni / ethanol / 5 h / 20 °C

3.1: sodium methylate; methanol / 1.5 h / Reflux

4.1: trifluoroacetic acid / dichloromethane / 10 °C

4.2: 100 °C

5.1: caesium carbonate; XPhos / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 16 h / 90 °C / Inert atmosphere; sealed flask

6.1: caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / palladium diacetate / 1,4-dioxane / 100 °C / Inert atmosphere

7.1: dichloromethane / 1 h

With methanol; ammonia; hydrogen; sodium methylate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; trifluoroacetic acid; XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium diacetate; In 1,4-dioxane; ethanol; dichloromethane; chloroform;