3,5-Pyridinedicarboxylic acid, 4-(2,3-dichlorophenyl)-2-[[2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)eth oxy]methyl]-1,4-dihydro-6-methyl-, diethyl ester

Base Information

• Chemical Name: 3,5-Pyridinedicarboxylic acid, 4-(2,3-dichlorophenyl)-2-[[2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)eth oxy]methyl]-1,4-dihydro-6-methyl-, diethyl ester
• CAS No.: 103198-42-1
• Molecular Formula: C₂₉H₂₈Cl₂N₂O₇
• Molecular Weight: 587.457
• Mol file: 103198-42-1.mol

Synonyms:

Chemical Property of 3,5-Pyridinedicarboxylic acid, 4-(2,3-dichlorophenyl)-2-[[2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)eth oxy]methyl]-1,4-dihydro-6-methyl-, diethyl ester

Chemical Property:

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MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,5-Pyridinedicarboxylic acid, 4-(2,3-dichlorophenyl)-2-[[2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)eth oxy]methyl]-1,4-dihydro-6-methyl-, diethyl ester

There total 2 articles about 3,5-Pyridinedicarboxylic acid, 4-(2,3-dichlorophenyl)-2-[[2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)eth oxy]methyl]-1,4-dihydro-6-methyl-, diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

ethyl 3-aminobut-2-enoate (626-34-6) + ethyl 4-[2-(phthalimido)ethoxy]acetoacetate (88150-75-8) + 2,3-dichlorobenzylaldehyde (6334-18-5) → 4-(2,3-Dichloro-phenyl)-2-[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-ethoxymethyl]-6-methyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid diethyl ester (103198-42-1)

Guidance literature:

Heating;

DOI:10.1016/0223-5234(91)90132-7

Reference yield:

ethyl acetoacetate (141-97-9) → 4-(2,3-Dichloro-phenyl)-2-[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-ethoxymethyl]-6-methyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid diethyl ester (103198-42-1)

Guidance literature:

Multi-step reaction with 2 steps

1: NH₃ / ethanol

2: 27 percent / Heating

With ammonia; In ethanol;

DOI:10.1016/0223-5234(91)90132-7

Reference yield:

4-(2,3-Dichloro-phenyl)-2-[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-ethoxymethyl]-6-methyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid diethyl ester (103198-42-1) → 2-(2-Amino-ethoxymethyl)-4-(2,3-dichloro-phenyl)-6-methyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid diethyl ester (103198-55-6)

Guidance literature:

With methylamine; Ambient temperature;

DOI:10.1016/0223-5234(91)90132-7

upstream raw materials:

ethyl 3-aminobut-2-enoate

ethyl 4-[2-(phthalimido)ethoxy]acetoacetate

2,3-dichlorobenzylaldehyde

ethyl acetoacetate

Downstream raw materials:

2-(2-Amino-ethoxymethyl)-4-(2,3-dichloro-phenyl)-6-methyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid diethyl ester

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