N-[1-(5-{4-[4-(3-Chloro-phenyl)-piperazin-1-yl]-7-trifluoromethyl-quinolin-3-yl}-[1,3,4]oxadiazol-2-yl)-2-(1H-indol-3-yl)-ethyl]-benzamide

Base Information

Chemical Name:N-[1-(5-{4-[4-(3-Chloro-phenyl)-piperazin-1-yl]-7-trifluoromethyl-quinolin-3-yl}-[1,3,4]oxadiazol-2-yl)-2-(1H-indol-3-yl)-ethyl]-benzamide
CAS No.:116247-38-2
Molecular Formula:C₃₉H₃₁ClF₃N₇O₂
Molecular Weight:722.169
Hs Code.:

Synonyms:

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Chemical Property of N-[1-(5-{4-[4-(3-Chloro-phenyl)-piperazin-1-yl]-7-trifluoromethyl-quinolin-3-yl}-[1,3,4]oxadiazol-2-yl)-2-(1H-indol-3-yl)-ethyl]-benzamide

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Technology Process of N-[1-(5-{4-[4-(3-Chloro-phenyl)-piperazin-1-yl]-7-trifluoromethyl-quinolin-3-yl}-[1,3,4]oxadiazol-2-yl)-2-(1H-indol-3-yl)-ethyl]-benzamide

There total 3 articles about N-[1-(5-{4-[4-(3-Chloro-phenyl)-piperazin-1-yl]-7-trifluoromethyl-quinolin-3-yl}-[1,3,4]oxadiazol-2-yl)-2-(1H-indol-3-yl)-ethyl]-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 116247-32-6
N-[1-[5-(4-Chloro-7-trifluoromethyl-quinolin-3-yl)-[1,3,4]oxadiazol-2-yl]-2-(1H-indol-3-yl)-ethyl]-benzamide

: 6640-24-0
N-(m-chlorophenyl)piperazine

: 116247-38-2
N-[1-(5-{4-[4-(3-Chloro-phenyl)-piperazin-1-yl]-7-trifluoromethyl-quinolin-3-yl}-[1,3,4]oxadiazol-2-yl)-2-(1H-indol-3-yl)-ethyl]-benzamide

Guidance literature:: With pyridine; In ethanol; Heating;

Reference yield:

: 391-02-6
4-hydroxy-7-trifluoromethyl-quinoline-3-carboxylic acid ethyl ester

: 116247-38-2
N-[1-(5-{4-[4-(3-Chloro-phenyl)-piperazin-1-yl]-7-trifluoromethyl-quinolin-3-yl}-[1,3,4]oxadiazol-2-yl)-2-(1H-indol-3-yl)-ethyl]-benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: 70 percent / hydrazine hydrate / 16 h / Heating

2: 60 percent / POCl₃ / Heating

3: 45 percent / pyridine / ethanol / Heating

With pyridine; hydrazine hydrate; trichlorophosphate; In ethanol;

Reference yield:

: 116247-30-4
7-Trifluoromethyl-4-hydroxyquinoline-3-carboxylic acid hydrazide

: 116247-38-2
N-[1-(5-{4-[4-(3-Chloro-phenyl)-piperazin-1-yl]-7-trifluoromethyl-quinolin-3-yl}-[1,3,4]oxadiazol-2-yl)-2-(1H-indol-3-yl)-ethyl]-benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: 60 percent / POCl₃ / Heating

2: 45 percent / pyridine / ethanol / Heating

With pyridine; trichlorophosphate; In ethanol;