N-Boc-PEG5-alcohol

Base Information

• Chemical Name: N-Boc-PEG5-alcohol
• CAS No.: 1404111-67-6
• Molecular Formula: C₁₅H₃₁NO₇
• Molecular Weight: 337.414
• Hs Code.: 2924190090
• Mol file: 1404111-67-6.mol

Synonyms:

Chemical Property of N-Boc-PEG5-alcohol

Chemical Property:

• Boiling Point: 451.5±40.0 °C(Predicted)
• PKA: 12.23±0.46(Predicted)
• Density: 1.083±0.06 g/cm3(Predicted)
• Solubility.: Soluble in DCM, Methanol

Purity/Quality:

98%,99%, ^*data from raw suppliers

N-Boc-Peg5-Alcohol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Description: N-Boc-PEG5-alcohol is a PEG linker containing a hydroxyl group and Boc-protected amino group. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The Boc group can be deprotected under mild acidic conditions to form the free amine.

Technology Process of N-Boc-PEG5-alcohol

There total 16 articles about N-Boc-PEG5-alcohol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

di-tert-butyl dicarbonate (24424-99-5) + 2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethanol (86770-68-5) → tert-butyl N-[2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethyl]carbamate (1404111-67-6)

Guidance literature:

With palladium on activated charcoal; triethylamine; In ethyl acetate; at 20 ℃; for 29h;

DOI:10.1021/jacs.7b09713

Reference yield: 86.3%

di-tert-butyl dicarbonate (24424-99-5) + [2-(2-{2-[2-(2-benzyloxyethoxy)ethoxy]ethoxy}ethoxy)ethyl]tritylamine → tert-butyl N-[2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethyl]carbamate (1404111-67-6)

Guidance literature:

[2-(2-{2-[2-(2-benzyloxyethoxy)ethoxy]ethoxy}ethoxy)ethyl]tritylamine; With hydrogenchloride; palladium on activated charcoal; hydrogen; In ethanol; water; at 50 ℃; for 10h;

di-tert-butyl dicarbonate; In water; Reagent/catalyst; Temperature;

Reference yield: 79.0%

di-tert-butyl dicarbonate (24424-99-5) + benzyl N-[2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethyl]carbamate → tert-butyl N-[2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethyl]carbamate (1404111-67-6)

Guidance literature:

With 10% palladium hydroxide on charcoal; hydrogen; In ethyl acetate; at 20 ℃; for 16h; under 775.743 Torr;

upstream raw materials:

2-(2-(2-aminoethoxy)ethoxy)ethan-1-ol

2,2-dimethyl-4-oxo-3,8,11-trioxa-5-azatridecane-13-yl methanesulfonate

diethylene glycol

tert-butyl 2-(2-(2-hydroxyethoxy)ethoxy)ethylcarbamate

Downstream raw materials:

2-[2-[2-[2-[2-[2-(tert-butoxycarbonylamino)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]acetic acid

tert-butyl [2-(2-{2-[2-(2-azidoethoxy)ethoxy]ethoxy}ethoxy)ethyl]carbamate

tert-butyl N-[2-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]ethyl]carbamate