1-Bromo-4-[(4-chlorophenyl)methyl]benzene

Base Information

• Chemical Name: 1-Bromo-4-[(4-chlorophenyl)methyl]benzene
• CAS No.: 30203-84-0
• Molecular Formula: C13H10 Br Cl
• Molecular Weight: 281.579
• Hs Code.: 2903999090
• NSC Number: 97073
• DSSTox Substance ID: DTXSID20952592
• Nikkaji Number: J307.824H
• Wikidata: Q82931242
• Mol file: 30203-84-0.mol

Synonyms:30203-84-0;1-bromo-4-[(4-chlorophenyl)methyl]benzene;NSC97073;SCHEMBL1773908;DTXSID20952592;1-(4-Bromobenzyl)-4-chlorobenzene;NSC-97073;Methane, (p-bromophenyl)-(p-chlorophenyl)-

Chemical Property of 1-Bromo-4-[(4-chlorophenyl)methyl]benzene

Chemical Property:

• Vapor Pressure: 0.000128mmHg at 25°C
• Boiling Point: 344.8°C at 760 mmHg
• Flash Point: 189°C
• PSA: 0.00000
• Density: 1.429g/cm³
• LogP: 4.69330
• XLogP3: 4.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 0
• Rotatable Bond Count: 2
• Exact Mass: 279.96544
• Heavy Atom Count: 15
• Complexity: 179

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC=C1CC2=CC=C(C=C2)Br)Cl

Technology Process of 1-Bromo-4-[(4-chlorophenyl)methyl]benzene

There total 14 articles about 1-Bromo-4-[(4-chlorophenyl)methyl]benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

1-((4-bromophenyl)-(4-chlorophenyl))methanol (105901-10-8) → 1-bromo-4-(4-chlorobenzyl)benzene (30203-84-0)

Guidance literature:

With sodium tetrahydroborate; trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 2h;

DOI:10.1021/acs.orglett.6b00430

Reference yield: 82.0%

1-Chloro-4-iodobenzene (637-87-6) + bromo-[(4-bromophenyl)methyl]zinc (115055-85-1) → 1-bromo-4-(4-chlorobenzyl)benzene (30203-84-0)

Guidance literature:

With trifuran-2-yl-phosphane; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; at 25 ℃;

DOI:10.1016/S0040-4039(97)00187-1

Reference yield: 48.0%

4-Chlorophenylboronic acid (1679-18-1) + hydrazone of p-bromobenzaldehyde (57477-93-7) → 1-bromo-4-(4-chlorobenzyl)benzene (30203-84-0)

Guidance literature:

With manganese(IV) oxide; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 25 ℃; under 5171.62 Torr; Flow reactor;

DOI:10.1039/c4sc03072a

upstream raw materials:

1-(p-bromobenzyl)-2-t-butyl-4-(p-fluorophenyl)-6-phenylpyridinium trifluoromethanesulphonate

chlorobenzene

2-(4-bromo-phenyl)-1,1,1-trichloro-2-(4-chloro-phenyl)-ethane

1-((4-bromophenyl)-(4-chlorophenyl))methanol

Downstream raw materials:

1-chloro-4-(4-methylbenzyl)benzene

1-bromo-4-(4-methylbenzyl)benzene

4-bromo-4'-chlorobenzophenone