1-(α-hydroxyethyl)-1'-diphenylphosphinoferrocene

Base Information

Chemical Name:1-(α-hydroxyethyl)-1'-diphenylphosphinoferrocene
CAS No.:85150-23-8
Molecular Formula:C₂₄H₂₃FeOP
Molecular Weight:414.267
Hs Code.:

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Chemical Property of 1-(α-hydroxyethyl)-1'-diphenylphosphinoferrocene

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Technology Process of 1-(α-hydroxyethyl)-1'-diphenylphosphinoferrocene

There total 1 articles about 1-(α-hydroxyethyl)-1'-diphenylphosphinoferrocene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 85150-21-6
1-acetyl-1'-diphenylphosphinoferrocene

: 141-78-6
ethyl acetate

: 85150-23-8
1-(α-hydroxyethyl)-1'-diphenylphosphinoferrocene

Guidance literature:: With lithium aluminium tetrahydride; In benzene; under N2 atm. soln. (η5-(C6H5)2PC5H4)Fe(η5-CH3C(O)C5H4) in benzene added slowly to stirred suspn. LiAlH4 in benzene and soln. stirred for 1 h at room temp., ethyl acetate added dropwise followed by water; org. layer separated and dried over anhyd. MgSO4, solvent volume reduceunder vac., residue chromed on alumina, solvent removed under vac., residue dried (50°C) in vacuo and crystd. from hexane; elem. anal.;

Reference yield: 49.0%

: 85150-23-8
1-(α-hydroxyethyl)-1'-diphenylphosphinoferrocene

: 124-40-3
dimethyl amine

: 85150-25-0,103948-69-2
(.eta5-(C6H5)2PC5H4)Fe(η5-(CH3C(H)NMe2)C5H4)

Guidance literature:: With acetic anhydride; In pyridine; methanol; under N2 atm. (η5-(C6H5)2PC5H4)Fe(η5-CH3C(H)OHC5H4) in pyridinestirred with excess acetic anhydride for 20 h, soln. filtered, solvent removed under vac., residue redissolved in methanol, excess HNMe2 added and soln. stirred for 2 h; solvent removed under vac., residue chromed. on alumina, elution with Et2O; product identified by 1H NMR spectroscopy;

Reference yield:

: 85150-23-8
1-(α-hydroxyethyl)-1'-diphenylphosphinoferrocene

: 124-40-3
dimethyl amine

: 85150-24-9
(.eta5-(C6H5)2PC5H4)Fe(η5-(CH=CH2)C5H4)

: 85150-25-0,103948-69-2
(.eta5-(C6H5)2PC5H4)Fe(η5-(CH3C(H)NMe2)C5H4)

Guidance literature:: With hydrogen bromide; In benzene; under N2 atm. slowly bubbled through stirred soln. (η5-(C6H5)2PC5H4)Fe(η5-CH3C(H)OHC5H4) in benzene, excess HNMe2 added dropwise; ppt. filtered, soln. treated with Et2O, ppt. filtered off, solvent volume reduced, oil chromed. on alumina, eluited with 50/50 hexane/ether mixt., poduct recrystd. from chloroform/ether; elem. anal.;