Tert-butyloxycarbonyltyrosyl-glycyl-glycyl-phenylalanyl-leucyl-ε-benzyloxycarbonyllysine Benzyl Ester

Base Information

• Chemical Name: Tert-butyloxycarbonyltyrosyl-glycyl-glycyl-phenylalanyl-leucyl-ε-benzyloxycarbonyllysine Benzyl Ester
• CAS No.: 98317-55-6
• Molecular Formula: C₅₄H₆₉N₇O₁₂
• Molecular Weight: 1008.18
• Mol file: 98317-55-6.mol

Synonyms:Tert-butyloxycarbonyltyrosyl-glycyl-glycyl-phenylalanyl-leucyl-ε-benzyloxycarbonyllysine Benzyl Ester

Chemical Property of Tert-butyloxycarbonyltyrosyl-glycyl-glycyl-phenylalanyl-leucyl-ε-benzyloxycarbonyllysine Benzyl Ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Tert-butyloxycarbonyltyrosyl-glycyl-glycyl-phenylalanyl-leucyl-ε-benzyloxycarbonyllysine Benzyl Ester

There total 5 articles about Tert-butyloxycarbonyltyrosyl-glycyl-glycyl-phenylalanyl-leucyl-ε-benzyloxycarbonyllysine Benzyl Ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

Lys(Z)-OBzl (24458-14-8) + N-tert-butyloxycarbonyl-L-tyrosyl-glycyl-glycyl-L-phenylalanyl-L-leucine (64963-27-5) → Tert-butyloxycarbonyltyrosyl-glycyl-glycyl-phenylalanyl-leucyl-ε-benzyloxycarbonyllysine Benzyl Ester (98317-55-6)

Guidance literature:

With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; at -20 - 0 ℃; for 1h; O deg C, overnight;

DOI:10.1135/cccc19851329

Reference yield:

Boc-Tyr-OH (3978-80-1) → Tert-butyloxycarbonyltyrosyl-glycyl-glycyl-phenylalanyl-leucyl-ε-benzyloxycarbonyllysine Benzyl Ester (98317-55-6)

Guidance literature:

Multi-step reaction with 5 steps

1: 72 percent / 1-hydroxybenzotriazol, dicyclohexylcarbodiimide / dimethylformamide / 1 h / 0 °C

2: hydrogen / palladium black / 2-methyl-propan-2-ol / 8 h

3: dicyclohexylcarbodiimide / CHCl₃ / 3 h / -20 - 0 °C / r.t., overnight

4: 86 percent / hydrogen / palladium black / 2-methyl-propan-2-ol / 16 h

5: 57 percent / 1-hydroxybenzotriazol, dicyclohexylcarbodiimide / dimethylformamide / 1 h / -20 - 0 °C / O deg C, overnight

With hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; palladium; In chloroform; N,N-dimethyl-formamide; tert-butyl alcohol;

DOI:10.1135/cccc19851329

Reference yield:

tert-butoxycarbonyl-L-tyrosyl-glycyl-glycine (59481-76-4) → Tert-butyloxycarbonyltyrosyl-glycyl-glycyl-phenylalanyl-leucyl-ε-benzyloxycarbonyllysine Benzyl Ester (98317-55-6)

Guidance literature:

Multi-step reaction with 3 steps

1: dicyclohexylcarbodiimide / CHCl₃ / 3 h / -20 - 0 °C / r.t., overnight

2: 86 percent / hydrogen / palladium black / 2-methyl-propan-2-ol / 16 h

3: 57 percent / 1-hydroxybenzotriazol, dicyclohexylcarbodiimide / dimethylformamide / 1 h / -20 - 0 °C / O deg C, overnight

With hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; palladium; In chloroform; N,N-dimethyl-formamide; tert-butyl alcohol;

DOI:10.1135/cccc19851329

upstream raw materials:

Lys(Z)-OBzl

N-tert-butyloxycarbonyl-L-tyrosyl-glycyl-glycyl-L-phenylalanyl-L-leucine

Boc-Tyr-OH

tert-butoxycarbonyl-L-tyrosyl-glycyl-glycine

Downstream raw materials:

(S)-6-Amino-2-{(S)-2-[(S)-2-(2-{2-[(S)-2-tert-butoxycarbonylamino-3-(4-hydroxy-phenyl)-propionylamino]-acetylamino}-acetylamino)-3-phenyl-propionylamino]-4-methyl-pentanoylamino}-hexanoic acid

Tyrosyl-glycyl-glycyl-phenylalanyl-leucyl-lysine