(Z)-α-(methylthio)styryl methyl sulfoxide

Base Information

• Chemical Name: (Z)-α-(methylthio)styryl methyl sulfoxide
• CAS No.: 35453-10-2
• Molecular Formula: C₁₀H₁₂OS₂
• Molecular Weight: 212.337
• Mol file: 35453-10-2.mol

Synonyms:

Chemical Property of (Z)-α-(methylthio)styryl methyl sulfoxide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (Z)-α-(methylthio)styryl methyl sulfoxide

There total 4 articles about (Z)-α-(methylthio)styryl methyl sulfoxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl phenyldithioacetate (2168-85-6) + methyl iodide (74-88-4) → (Z)-α-(methylthio)styryl methyl sulfoxide (35453-10-2) + methyl[(E)-1-(methylsulfinyl)-2-phenylvinyl]sulfane (35453-05-5)

Guidance literature:

methyl phenyldithioacetate; With methyllithium; In tetrahydrofuran; diethyl ether; at -78 ℃; for 0.25h;

With rac N-phenylsulfonyl tert-butyl methyl oxaziridine; In tetrahydrofuran; diethyl ether; at -78 ℃; for 0.333333h;

methyl iodide; In tetrahydrofuran; diethyl ether; at -78 ℃; for 5h;

DOI:10.1021/jo0492362

Reference yield:

benzaldehyde (100-52-7) → (Z)-α-(methylthio)styryl methyl sulfoxide (35453-10-2) + methyl[(E)-1-(methylsulfinyl)-2-phenylvinyl]sulfane (35453-05-5)

Guidance literature:

Multi-step reaction with 2 steps

1: n-butyllithium

2: potassium tert-butylate / toluene; tert-butyl alcohol

With n-butyllithium; potassium tert-butylate; In toluene; tert-butyl alcohol;

DOI:10.1246/bcsj.20140241

Reference yield:

Acetic acid 2-methanesulfinyl-2-methylsulfanyl-1-phenyl-ethyl ester (52977-22-7) → (Z)-α-(methylthio)styryl methyl sulfoxide (35453-10-2) + methyl[(E)-1-(methylsulfinyl)-2-phenylvinyl]sulfane (35453-05-5)

Guidance literature:

With potassium tert-butylate; In toluene; tert-butyl alcohol;

DOI:10.1246/bcsj.20140241

upstream raw materials:

methyl phenyldithioacetate

methyl iodide

benzaldehyde

Acetic acid 2-methanesulfinyl-2-methylsulfanyl-1-phenyl-ethyl ester

Downstream raw materials:

(E)-β-(methylthio)styrene