Ethyl 4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-3-carboxylate

Base Information

• Chemical Name: Ethyl 4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-3-carboxylate
• CAS No.: 118055-06-4
• Molecular Formula: C₁₀H₁₄N₂O₂
• Molecular Weight: 194.233
• Hs Code.: 2933990090
• European Community (EC) Number: 849-641-5
• DSSTox Substance ID: DTXSID80556550
• Nikkaji Number: J1.726.373K
• Wikidata: Q82438129
• Mol file: 118055-06-4.mol

Synonyms:118055-06-4;ethyl 4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-3-carboxylate;4,5,6,7-Tetrahydro-pyrazolo[1,5-a]pyridine-3-carboxylic acid ethyl ester;ethyl 4H,5H,6H,7H-pyrazolo[1,5-a]pyridine-3-carboxylate;SCHEMBL2929945;DTXSID80556550;ethyl4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-3-carboxylate;MFCD17011856;AKOS015854368;AS-47683;EN300-244258;F15264;F1913-0573

Chemical Property of Ethyl 4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-3-carboxylate

Chemical Property:

• PSA: 44.12000
• LogP: 1.39610
• XLogP3: 1.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 194.105527694
• Heavy Atom Count: 14
• Complexity: 220

Purity/Quality:

97% ^*data from raw suppliers

4,5,6,7-Tetrahydro-pyrazolo[1,5-a]pyridine-3-carboxylicAcidEthylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(=O)C1=C2CCCCN2N=C1

Technology Process of Ethyl 4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-3-carboxylate

There total 14 articles about Ethyl 4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

Pyrazolo<1,5-a>pyridin-3-carbonsaeureethylester (16205-44-0) → 4,5,6,7-Tetrahydropyrazolo<1,5-a>pyridin-3-carbonsaeureethylester (118055-06-4)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethanol; water; Flow reactor; Heating;

DOI:10.1002/ejoc.201801684

Reference yield: 65.0%

4,5,6,7-tetrahydro<1.2.3>oxadiazolo<3,4-a>pyridin-3-one (105786-95-6) + propynoic acid ethyl ester (623-47-2) → 4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-2-carboxylic acid ethyl ester (307307-84-2) + 4,5,6,7-Tetrahydropyrazolo<1,5-a>pyridin-3-carbonsaeureethylester (118055-06-4)

Guidance literature:

In o-xylene; for 16h; Heating;

DOI:10.1021/jm060021p

Reference yield: 60.0%

C10H15BF3N2O2(1-)*K(1+) → 4,5,6,7-Tetrahydropyrazolo<1,5-a>pyridin-3-carbonsaeureethylester (118055-06-4)

Guidance literature:

With dipotassium peroxodisulfate; silver nitrate; In water; 4-methyl-1,2,3-trifluorobenzene; at 60 ℃; for 1h;

DOI:10.1021/ol2023505

upstream raw materials:

Pyrazolo<1,5-a>pyridin-3-carbonsaeureethylester

4,5,6,7-tetrahydro<1.2.3>oxadiazolo<3,4-a>pyridin-3-one

propynoic acid ethyl ester

4-ethoxycarbonylpyrazole

Downstream raw materials:

Methyl-3-(4-benzyloxymethyl-4,5,6,7-tetrahydropyrazolo<1,5-a>pyridine-3-yl)-3-oxo-propionate

C₂₀H₂₄F₂N₄O

4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-3-carboxylic acid