1,2,3,5-Tetrachloro-4,6-difluorobenzene

Base Information

• Chemical Name: 1,2,3,5-Tetrachloro-4,6-difluorobenzene
• CAS No.: 1198-56-7
• Molecular Formula: C6Cl4F2
• Molecular Weight: 251.875
• Hs Code.: 2903999090
• DSSTox Substance ID: DTXSID20347303
• Nikkaji Number: J103.484G
• Wikidata: Q82121074
• Mol file: 1198-56-7.mol

Synonyms:1,2,3,5-Tetrachloro-4,6-difluorobenzene;m-Difluorotetrachlorobenzene;1198-56-7;Benzene, 1,2,3,5-tetrachloro-4,6-difluoro-;1,3-difluorotetrachlorobenzene;SCHEMBL4449502;DTXSID20347303;1,3-difluoro-2,4,5,6-tetrachlorobenzene;1,2,3,5-Tetrachloro-4,6-difluorobenzene #

Chemical Property of 1,2,3,5-Tetrachloro-4,6-difluorobenzene

Chemical Property:

• PSA: 0.00000
• LogP: 4.57840
• XLogP3: 4.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 251.869267
• Heavy Atom Count: 12
• Complexity: 152

Purity/Quality:

98%,99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1(=C(C(=C(C(=C1Cl)Cl)Cl)F)Cl)F

Technology Process of 1,2,3,5-Tetrachloro-4,6-difluorobenzene

There total 11 articles about 1,2,3,5-Tetrachloro-4,6-difluorobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 13.5%

hexachlorobenzene (118-74-1,67471-27-6) → 1-chloro-2,3,4,5,6-pentafluorobenzene (344-07-0) + 1,4-dichloro-2,3,5,6-tetrafluorobenzene (1198-62-5) + 1,2,4-trichlorotrifluorobenzene (827-13-4) + 1,2,3,5-tetrachloro-4,6-difluorobenzene (1198-56-7)

Guidance literature:

With potassium fluoride; tetrakis(diethylamino)phosphonium bromide; at 220 ℃; for 24h; under 4940 Torr; Further Variations:; Reagents; Temperatures; Product distribution;

Reference yield:

Hexafluorobenzene (392-56-3) → 1-chloro-2,3,4,5,6-pentafluorobenzene (344-07-0) + 1,3-dichloro-2,4,5,6-tetrafluorobenzene (1198-61-4) + 1,2,3,5-tetrachloro-4,6-difluorobenzene (1198-56-7) + 1,3,5-trichlorotrifluorobenzene (319-88-0)

Guidance literature:

With hexaethylguanidinium chloride; sodium chloride; at 130 - 140 ℃; for 48h; Further Variations:; Reagents; Temperatures; Product distribution;

DOI:10.1023/B:RUJO.0000045890.17421.42

Reference yield:

hexachlorobenzene (118-74-1,67471-27-6) → pentachlorofluorobenzene (319-87-9) + 1,2,3,5-tetrachloro-4,6-difluorobenzene (1198-56-7)

Guidance literature:

With F; In tetrahydrofuran; for 72h; Ambient temperature;

DOI:10.1021/ja00103a045

upstream raw materials:

1-chloro-3,5-difluorobenzene

2,4,5,6-Tetrabromo-1,3-difluorobenzene

1,3-Difluor-4,6-dichlor-2,5-dibrombenzol

hexachlorobenzene

Downstream raw materials:

2,4,5,6-Tetrachlor-1,3-phenylendiamin

1,3,5-trichlorotrifluorobenzene

2,4,5,6-Tetrachlor-1,3-phenylendiamintetraacetat