6,7-dichloro-2,3-dihydro-5-<3,5--4-hydroxybenzoyl>-2-benzofurancarboxylic acid

Base Information

• Chemical Name: 6,7-dichloro-2,3-dihydro-5-<3,5--4-hydroxybenzoyl>-2-benzofurancarboxylic acid
• CAS No.: 95250-14-9
• Molecular Formula: C₂₂H₂₄Cl₂N₂O₅
• Molecular Weight: 467.349

Synonyms:

Chemical Property of 6,7-dichloro-2,3-dihydro-5-<3,5--4-hydroxybenzoyl>-2-benzofurancarboxylic acid

Chemical Property:

Purity/Quality:

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Technology Process of 6,7-dichloro-2,3-dihydro-5-<3,5--4-hydroxybenzoyl>-2-benzofurancarboxylic acid

There total 2 articles about 6,7-dichloro-2,3-dihydro-5-<3,5--4-hydroxybenzoyl>-2-benzofurancarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6,7-Dichloro-2,3-dihydro-5-(p-nitrobenzoyl)-benzofuran-2-carboxylic acid (90246-58-5) → 6,7-dichloro-2,3-dihydro-5-<3,5--4-hydroxybenzoyl>-2-benzofurancarboxylic acid (95250-14-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 73 percent / acetaldoxime, NaOH / dimethylformamide / Ambient temperature

2: 1.) water, RT, 0.25 h, 2.) water, reflux, 20 h

With sodium hydroxide; Acetaldehyde oxime; In N,N-dimethyl-formamide;

DOI:10.1021/jm50001a009

Reference yield:

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 6,7-Dichloro-2,3-dihydro-5-(p-hydroxybenzoyl)-benzofuran-2-carboxylic acid (90246-55-2) + dimethyl amine (124-40-3) → 6,7-dichloro-2,3-dihydro-5-<3,5--4-hydroxybenzoyl>-2-benzofurancarboxylic acid (95250-14-9)

Guidance literature:

Yield given. Multistep reaction; 1.) water, RT, 0.25 h, 2.) water, reflux, 20 h;

DOI:10.1021/jm50001a009

Reference yield:

ethanol (64-17-5) + 6,7-dichloro-2,3-dihydro-5-<3,5--4-hydroxybenzoyl>-2-benzofurancarboxylic acid (95250-14-9) → ethyl 6,7-dichloro-2,3-dihydro-5-<3,5-bis<(dimethylamino)methyl>-4-hydroxybenzoyl>-2-benzofurancarboxylate dihydrochloride (95250-05-8)

Guidance literature:

With thionyl chloride; for 4h; Yield given; Heating;

DOI:10.1021/jm50001a009

upstream raw materials:

formaldehyd

6,7-Dichloro-2,3-dihydro-5-(p-hydroxybenzoyl)-benzofuran-2-carboxylic acid

dimethyl amine

6,7-Dichloro-2,3-dihydro-5-(p-nitrobenzoyl)-benzofuran-2-carboxylic acid

Downstream raw materials:

ethyl 6,7-dichloro-2,3-dihydro-5-<3,5-bis<(dimethylamino)methyl>-4-hydroxybenzoyl>-2-benzofurancarboxylate dihydrochloride

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