4-(2,4-dichlorophenyl)-6-oxo-2-phenyl-1,6-dihydro-5-pyrimidinecarbonitrile

Base Information

Chemical Name:4-(2,4-dichlorophenyl)-6-oxo-2-phenyl-1,6-dihydro-5-pyrimidinecarbonitrile
CAS No.:761357-05-5
Molecular Formula:C₁₈H₁₄N₄O
Molecular Weight:302.335
Hs Code.:

Synonyms:4-(2,4-dichlorophenyl)-6-oxo-2-phenyl-1,6-dihydro-5-pyrimidinecarbonitrile

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Chemical Property of 4-(2,4-dichlorophenyl)-6-oxo-2-phenyl-1,6-dihydro-5-pyrimidinecarbonitrile

Chemical Property:

Melting Point:215-216 °C(Solv: ethanol (64-17-5))
Boiling Point:461.8±45.0 °C(Predicted)
Density:1.31±0.1 g/cm3(Predicted)

Purity/Quality:

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Technology Process of 4-(2,4-dichlorophenyl)-6-oxo-2-phenyl-1,6-dihydro-5-pyrimidinecarbonitrile

There total 4 articles about 4-(2,4-dichlorophenyl)-6-oxo-2-phenyl-1,6-dihydro-5-pyrimidinecarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1670-14-0
benzamidine monohydrochloride

: 123-11-5
4-methoxy-benzaldehyde

: 109-77-3
malononitrile

: 761357-05-5
4-(2,4-dichlorophenyl)-6-oxo-2-phenyl-1,6-dihydro-5-pyrimidinecarbonitrile

Guidance literature:: With iron oxide; In neat (no solvent); at 100 ℃;
DOI:10.1016/j.cclet.2013.04.035

Reference yield: 69.0%

: 1670-14-0
benzamidine monohydrochloride

: 129354-36-5
2-amino-3-cyano-7,7-dimethyl-4-(4-methoxyphenyl)-5-oxo-5,6,7,8-tetrahydro-4H-benzo[b]pyran

: 761357-05-5
4-(2,4-dichlorophenyl)-6-oxo-2-phenyl-1,6-dihydro-5-pyrimidinecarbonitrile

Guidance literature:: benzamidine monohydrochloride; With sodium; In ethanol; for 0.25h; cooling;

2-amino-3-cyano-7,7-dimethyl-4-(4-methoxyphenyl)-5-oxo-5,6,7,8-tetrahydro-4H-benzo[b]pyran; In ethanol; for 72h; Heating;
DOI:10.1002/jhet.5570410406

Reference yield:

: 2826-26-8
2-(4-methoxyphenylmethylene)malononitrile

: 618-39-3
benzamidin

: 761357-05-5
4-(2,4-dichlorophenyl)-6-oxo-2-phenyl-1,6-dihydro-5-pyrimidinecarbonitrile

Guidance literature:: 2-(4-methoxyphenylmethylene)malononitrile; benzamidin; With potassium carbonate; In methanol; at 50 ℃; for 3h;

With potassium permanganate; In acetone; at 20 ℃; for 3h;
DOI:10.1016/j.bmcl.2004.01.019 DOI:10.2533/000942904777677542