Azido-PEG4-CH2CO2H

Base Information

• Chemical Name: Azido-PEG4-CH2CO2H
• CAS No.: 1694731-93-5
• Molecular Formula: C₁₁H₁₈O₆
• Molecular Weight: 246.26
• Hs Code.: 2918999090
• Mol file: 1694731-93-5.mol

Synonyms:

Chemical Property of Azido-PEG4-CH2CO2H

Chemical Property:

• Boiling Point: 375.0±32.0 °C(Predicted)
• PKA: 3.39±0.10(Predicted)
• Density: 1.151±0.06 g/cm3(Predicted)

Purity/Quality:

98%,99%, ^*data from raw suppliers

Propargyl-PEG4-CH2CO2H 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Description: Propargyl-PEG4-CH2CO2H is a linker consisting of a propargyl group with a carboxylic acid group. The carboxylic acid can react with primary amine groups in the presence of activators such as HATU or EDC. The propargyl group can react with azide compounds in Click Chemistry; copper catalyst will be needed. The PEG units help the molecule to have better solubility in aqueous solution.

Technology Process of Azido-PEG4-CH2CO2H

There total 5 articles about Azido-PEG4-CH2CO2H which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

3,6,9,12-tetraoxapentadec-14-yn-1-ol (87450-10-0) → C11H18O6 (1694731-93-5)

Guidance literature:

With Jones reagent; In acetone; for 3h;

DOI:10.1039/C8RA08794F

Reference yield:

tert-butyl-2-(2-{2-[2-(prop-2-ynyloxy)ethoxy]ethoxy}ethoxy)acetate (888010-02-4) → C11H18O6 (1694731-93-5)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 15 ℃; for 1h;

DOI:10.1021/acs.jmedchem.6b01781

Reference yield:

Tetraethylene glycol (112-60-7) → C11H18O6 (1694731-93-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran / 0 °C

1.2: 24.5 h / 0 - 20 °C

2.1: Jones reagent / acetone / 3 h

With Jones reagent; sodium hydride; In tetrahydrofuran; acetone;

DOI:10.1039/C8RA08794F

upstream raw materials:

2,2'-[1,2-ethanediylbis(oxy)]bisethanol

O-propargyl triethylene glycol

tert-butyl-2-(2-{2-[2-(prop-2-ynyloxy)ethoxy]ethoxy}ethoxy)acetate

3,6,9,12-tetraoxapentadec-14-yn-1-ol

Refernces

• 1、 Wurz, Ryan P.,Dellamaggiore, Ken,Dou, Hannah,Javier, Noelle,Lo, Mei-Chu,McCarter, John D.,Mohl, Dane,Sastri, Christine,Lipford, J. Russell,Cee, Victor J.. "A "click Chemistry Platform" for the Rapid Synthesis of Bispecific Molecules for Inducing Protein Degradation". . p. 453 - 461. Retrieved 2018/02/07.