[(E)-3-Chloro-1-dimethylamino-3-(4-methoxy-phenyl)-allyl]-phosphonic acid dimethyl ester; compound with perchloric acid

Base Information

• Chemical Name: [(E)-3-Chloro-1-dimethylamino-3-(4-methoxy-phenyl)-allyl]-phosphonic acid dimethyl ester; compound with perchloric acid
• CAS No.: 75784-25-7
• Molecular Formula: C₁₄H₂₁ClNO₄P*ClHO₄
• Molecular Weight: 434.21
• Mol file: 75784-25-7.mol

Synonyms:

Chemical Property of [(E)-3-Chloro-1-dimethylamino-3-(4-methoxy-phenyl)-allyl]-phosphonic acid dimethyl ester; compound with perchloric acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [(E)-3-Chloro-1-dimethylamino-3-(4-methoxy-phenyl)-allyl]-phosphonic acid dimethyl ester; compound with perchloric acid

There total 4 articles about [(E)-3-Chloro-1-dimethylamino-3-(4-methoxy-phenyl)-allyl]-phosphonic acid dimethyl ester; compound with perchloric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

<3-chloro-3-(4-methoxyphenyl)-2-propen-1-yliden> dimethyliminium perchlorate (39812-29-8) + phosphorous acid trimethyl ester (121-45-9) → [(E)-3-Chloro-1-dimethylamino-3-(4-methoxy-phenyl)-allyl]-phosphonic acid dimethyl ester; compound with perchloric acid (75784-25-7)

Guidance literature:

In methanol; Heating;

Reference yield:

[(Z)-3-Chloro-1-hydroxy-3-(4-methoxy-phenyl)-allyl]-phosphonic acid dimethyl ester → [(E)-3-Chloro-1-dimethylamino-3-(4-methoxy-phenyl)-allyl]-phosphonic acid dimethyl ester; compound with perchloric acid (75784-25-7)

Guidance literature:

Multi-step reaction with 2 steps

1: SOCl₂ / CHCl₃ / 60 - 70 °C

2: benzene / 0.5 h

With thionyl chloride; In chloroform; benzene;

Reference yield:

[(Z)-1,3-Dichloro-3-(4-methoxy-phenyl)-allyl]-phosphonic acid dimethyl ester + dimethyl amine (124-40-3) → [(E)-3-Chloro-1-dimethylamino-3-(4-methoxy-phenyl)-allyl]-phosphonic acid dimethyl ester; compound with perchloric acid (75784-25-7)

Guidance literature:

In benzene; for 0.5h;

upstream raw materials:

dimethyl amine

<3-chloro-3-(4-methoxyphenyl)-2-propen-1-yliden> dimethyliminium perchlorate

Dimethyl phosphite

phosphorous acid trimethyl ester

Downstream raw materials:

[(E)-3-Chloro-1-dimethylamino-3-(4-methoxy-phenyl)-allyl]-phosphonic acid dimethyl ester