α-(6-Methoxy-2-naphthyl)lactic Acid

Base Information

• Chemical Name: α-(6-Methoxy-2-naphthyl)lactic Acid
• CAS No.: 32721-11-2
• Molecular Formula: C₁₄H₁₄O₄
• Molecular Weight: 246.263
• Mol file: 32721-11-2.mol

Synonyms:

Chemical Property of α-(6-Methoxy-2-naphthyl)lactic Acid

Chemical Property:

• Melting Point: 170 °C (decomp)
• Boiling Point: 463.7±30.0 °C(Predicted)
• PKA: 3.62±0.25(Predicted)
• Density: 1.297±0.06 g/cm3(Predicted)

Purity/Quality:

>95% ^*data from raw suppliers

α-(6-Methoxy-2-naphthyl)lacticAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: α-(6-Methoxy-2-naphthyl)lactic Acid is in intermediate used in the synthesis of Naproxen (N377525), an NSAID.

Technology Process of α-(6-Methoxy-2-naphthyl)lactic Acid

There total 1 articles about α-(6-Methoxy-2-naphthyl)lactic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

trichlorofluoromethane (75-69-4) + 6-methoxy-2-acetylnaphthalene (3900-45-6) → naproxen (23981-80-8) + 2-(6'-methoxy-2'-naphthyl)-2-hydroxypropionic acid (118854-23-2,32721-11-2) + C26H24O2

Guidance literature:

With lithium aluminium tetrahydride; titanium tetrachloride; In tetrahydrofuran; at -5 ℃; for 0.5h;

DOI:10.1016/S0040-4039(00)61527-7

Reference yield: 95.0%

dilauryl thiodipropionate (20611-90-9) + 2,6-di-tert-butyl-4-methyl-phenol (128-37-0) + 2-(6'-methoxy-2'-naphthyl)-2-hydroxypropionic acid (118854-23-2,32721-11-2) + 1,2-dichloro-benzene (95-50-1) → 2-(6-methoxynaphth-2-yl)acrylic acid (27602-79-5)

Guidance literature:

Reference yield:

2-(6'-methoxy-2'-naphthyl)-2-hydroxypropionic acid (118854-23-2,32721-11-2) → naproxen (23981-80-8)

Guidance literature:

With formic acid; palladium on activated charcoal; In hexane; for 6h; Yield given; Ambient temperature;

DOI:10.1016/S0040-4020(01)81926-8

upstream raw materials:

trichlorofluoromethane

6-methoxy-2-acetylnaphthalene

Downstream raw materials:

naproxen

2-(6-methoxynaphth-2-yl)acrylic acid

Refernces