5-Chloro-2,6-dimethyl-4(3H)-pyrimidone

Base Information

• Chemical Name: 5-Chloro-2,6-dimethyl-4(3H)-pyrimidone
• CAS No.: 20551-34-2
• Molecular Formula: C₆H₇ClN₂O
• Molecular Weight: 158.587
• Mol file: 20551-34-2.mol

Synonyms:

Chemical Property of 5-Chloro-2,6-dimethyl-4(3H)-pyrimidone

Chemical Property:

• Melting Point: 201 °C
• Boiling Point: 217.4±50.0 °C(Predicted)
• PKA: 8.11±0.50(Predicted)
• Density: 1.38±0.1 g/cm3(Predicted)

Purity/Quality:

99% ^*data from raw suppliers

5-Chloro-2,6-dimethylpyrimidin-4-ol 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Chloro-2,6-dimethyl-4(3H)-pyrimidone

There total 9 articles about 5-Chloro-2,6-dimethyl-4(3H)-pyrimidone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

(Dichloroiodo)benzene (932-72-9) + 4-hydroxy 2,6-dimethylpyrimidine (6622-92-0) → 5-chloro-2,6-dimethylpyrimidin-4-ol (20551-34-2)

Guidance literature:

With acetic acid; at 80 ℃; for 1h;

DOI:10.1002/hc.20608

Reference yield: 58.8%

acetamidine (143-37-3) + ethyl 2-chloro-3-oxo-butyrate (609-15-4) → 5-chloro-2,6-dimethylpyrimidin-4-ol (20551-34-2)

Guidance literature:

With potassium tert-butylate; In methanol; at 0 ℃; for 4.5h; Reflux;

DOI:10.1021/jm501207r

Reference yield:

acetamidine hydrochloride (124-42-5) + ethyl 2-chloro-3-oxo-butyrate (609-15-4) → 5-chloro-2,6-dimethylpyrimidin-4-ol (20551-34-2)

Guidance literature:

acetamidine hydrochloride; With sodium methylate; In methanol; for 0.5h;

ethyl 2-chloro-3-oxo-butyrate; In methanol; at -5 - 0 ℃; for 3h; Reflux;

DOI:10.1002/jhet.3710

upstream raw materials:

acetamidine

ethyl 2-chloro-3-oxo-butyrate

(Dichloroiodo)benzene

4-hydroxy 2,6-dimethylpyrimidine

Downstream raw materials:

4,5-dichloro-2,6-dimethylpyrimidine

Refernces

• 1、 Yan, Zhongzhong,Liu, Aiping,Ou, Yingcan,Li, Jianming,Yi,Zhang, Ning,Liu, Minhua,Huang, Lu,Ren, Jianwei,Liu, Weidong,Hu, Aixi. "Design, synthesis and fungicidal activity evaluation of novel pyrimidinamine derivatives containing phenyl-thiazole/oxazole moiety". . p. 3218 - 3228. Retrieved 2019/06/05.
• 2、 -. "ARYLOXYMETHYL CYCLOPROPANE DERIVATIVES AS PDE10 INHIBITORS". Paragraph 0164. . Retrieved 2016/10/31.