methyl 2,2-difluoro-1,3-benzodioxole-4-carboxylate

Base Information

• Chemical Name: methyl 2,2-difluoro-1,3-benzodioxole-4-carboxylate
• CAS No.: 531508-32-4
• Molecular Formula: C₉H₆F₂O₄
• Molecular Weight: 216.141
• Mol file: 531508-32-4.mol

Synonyms:

Chemical Property of methyl 2,2-difluoro-1,3-benzodioxole-4-carboxylate

Chemical Property:

• Boiling Point: 235.2±40.0 °C(Predicted)
• Density: 1.47±0.1 g/cm3(Predicted)

Purity/Quality:

97% ^*data from raw suppliers

Methyl2,2-difluoro-1,3-benzodioxole-4-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 2,2-difluoro-1,3-benzodioxole-4-carboxylate

There total 2 articles about methyl 2,2-difluoro-1,3-benzodioxole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

methanol (67-56-1) + 2,2-difluoro-1,3-benzodioxole-4-carboxylic acid (126120-85-2) → methyl 2,2-difluoro-1,3-benzodioxole-4-carboxylate (531508-32-4)

Guidance literature:

With boron trifluoride diethyl etherate; at 25 ℃; for 48h;

DOI:10.1002/ejoc.200390079

Reference yield: 81.0%

2,2-difluoro-1,3-benzodioxole (1583-59-1) + methyl chloroformate (79-22-1) → methyl 2,2-difluoro-1,3-benzodioxole-4-carboxylate (531508-32-4)

Guidance literature:

With sec.-butyllithium; In tetrahydrofuran; cyclohexane; at -75 ℃; for 2h;

DOI:10.1002/ejoc.200390079

Reference yield:

methyl 2,2-difluoro-1,3-benzodioxole-4-carboxylate (531508-32-4) → (2,2-difluorobenzo[d][1,3]dioxol-4-yl)methanamine (531508-46-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 56 percent / formamide; sodium methoxide / dimethylformamide / 6 h / 100 °C

2: 91 percent / thionyl chloride / 6 h / Heating

3: 86 percent / lithium aluminum hydride / diethyl ether / 2 h / Heating

With lithium aluminium tetrahydride; thionyl chloride; sodium methylate; formamide; In diethyl ether; N,N-dimethyl-formamide;

DOI:10.1002/ejoc.200390079

upstream raw materials:

methanol

2,2-difluoro-1,3-benzodioxole-4-carboxylic acid

2,2-difluoro-1,3-benzodioxole

methyl chloroformate

Downstream raw materials:

2,2-difluoro-1,3-benzodioxol-4-carbonitrile

(2,2-difluorobenzo[d][1,3]dioxol-4-yl)methanamine