(3RS,1'RS)-1-methyl-3-(1'-methyl-3'-phenyl-3'-((trimethylsilyl)oxy)-2'-propenyl)-2-pyrrolidinone

Base Information

• Chemical Name: (3RS,1'RS)-1-methyl-3-(1'-methyl-3'-phenyl-3'-((trimethylsilyl)oxy)-2'-propenyl)-2-pyrrolidinone
• CAS No.: 122969-56-6
• Molecular Formula: C₁₈H₂₇NO₂Si
• Molecular Weight: 317.503
• Mol file: 122969-56-6.mol

Synonyms:

Chemical Property of (3RS,1'RS)-1-methyl-3-(1'-methyl-3'-phenyl-3'-((trimethylsilyl)oxy)-2'-propenyl)-2-pyrrolidinone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3RS,1'RS)-1-methyl-3-(1'-methyl-3'-phenyl-3'-((trimethylsilyl)oxy)-2'-propenyl)-2-pyrrolidinone

There total 3 articles about (3RS,1'RS)-1-methyl-3-(1'-methyl-3'-phenyl-3'-((trimethylsilyl)oxy)-2'-propenyl)-2-pyrrolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-hydroxy-1-phenyl-butan-1-one (13505-39-0) → (3RS,1'RS)-1-methyl-3-(1'-methyl-3'-phenyl-3'-((trimethylsilyl)oxy)-2'-propenyl)-2-pyrrolidinone (122969-56-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) MsCl 2.) Et₃N

2: 1.) LDA / 1.) THF, -78 deg C 2.) 1.5 h, reflux

With methanesulfonyl chloride; triethylamine; lithium diisopropyl amide;

DOI:10.1021/jo00288a027

Reference yield:

acetophenone (98-86-2) → (3RS,1'RS)-1-methyl-3-(1'-methyl-3'-phenyl-3'-((trimethylsilyl)oxy)-2'-propenyl)-2-pyrrolidinone (122969-56-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 1) LDA / 1) THF,hexane, -78 deg C 2) -78 deg C

2: 1.) MsCl 2.) Et₃N

3: 1.) LDA / 1.) THF, -78 deg C 2.) 1.5 h, reflux

With methanesulfonyl chloride; triethylamine; lithium diisopropyl amide;

DOI:10.1021/jo00288a027

Reference yield:

1-methyl-pyrrolidin-2-one (872-50-4,26138-58-9) + chloro-trimethyl-silane (75-77-4) + (E)-1-phenyl-2-buten-1-one (35660-91-4,35845-66-0,495-41-0) → (3RS,1'RS)-1-methyl-3-(1'-methyl-3'-phenyl-3'-((trimethylsilyl)oxy)-2'-propenyl)-2-pyrrolidinone (122969-56-6)

Guidance literature:

With lithium diisopropyl amide; Yield given. Multistep reaction; 1.) THF, -78 deg C 2.) 1.5 h, reflux;

DOI:10.1021/jo00288a027

upstream raw materials:

1-methyl-pyrrolidin-2-one

chloro-trimethyl-silane

(E)-1-phenyl-2-buten-1-one

3-hydroxy-1-phenyl-butan-1-one

Refernces