2-Propenoic acid, 2-cyano-3-(4-methoxyphenyl)-, methyl ester, (E)-

Base Information

• Chemical Name: 2-Propenoic acid, 2-cyano-3-(4-methoxyphenyl)-, methyl ester, (E)-
• CAS No.: 14479-58-4
• Molecular Formula: C12H11NO3
• Molecular Weight: 217.224
• Hs Code.: 2926907090
• Mol file: 14479-58-4.mol

Synonyms:METHYL (E)-2-CYANO-3-(4-METHOXYPHENYL)ACRYLATE;methyl 2-cyano-3-(4-methoxyphenyl)acrylate;

Chemical Property of 2-Propenoic acid, 2-cyano-3-(4-methoxyphenyl)-, methyl ester, (E)-

Chemical Property:

• PSA: 59.32000
• LogP: 1.77518

Purity/Quality:

99% ^*data from raw suppliers

Methyl2-Cyano-3-(4-methoxyphenyl)acrylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Propenoic acid, 2-cyano-3-(4-methoxyphenyl)-, methyl ester, (E)-

There total 5 articles about 2-Propenoic acid, 2-cyano-3-(4-methoxyphenyl)-, methyl ester, (E)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-methoxy-benzaldehyde (123-11-5) + methyl 2-cyanoacetate (105-34-0) → methyl (E)- 2-cyano-3-(4-methoxyphenyl)prop-2-enoate (14479-58-4)

Guidance literature:

With aluminum oxide; Inert atmosphere; Neat (no solvent);

DOI:10.1039/c1ob06381b

Reference yield: 71.0%

trimethylsilyl cyanide (7677-24-9) + methyl 3-(4-methoxyphenyl)propynoate (7515-17-5) → methyl (E)- 2-cyano-3-(4-methoxyphenyl)prop-2-enoate (14479-58-4)

Guidance literature:

trimethylsilyl cyanide; With ethanol; In toluene; at 20 ℃; for 3h; Schlenk technique; Inert atmosphere;

methyl 3-(4-methoxyphenyl)propynoate; With diphenyl(methyl)phosphine; In toluene; at 20 ℃; for 24h; stereoselective reaction; Schlenk technique; Inert atmosphere;

DOI:10.1016/j.tet.2021.132457

Reference yield: 21.0%

p-Anisaldehyde dimethyl acetal (2186-92-7) + cyanoacetic acid (372-09-8) → methyl (E)- 2-cyano-3-(4-methoxyphenyl)prop-2-enoate (14479-58-4)

Guidance literature:

With lipase from Candida cylindracea; In toluene; at 50 ℃; for 96h; Enzymatic reaction;

DOI:10.1016/j.bioorg.2019.02.041

upstream raw materials:

4-methoxy-benzaldehyde

methyl 2-cyanoacetate

5-(4-methoxybenzylidene)-2,2-dimethyl-[1,3]dioxane-4,6-dione

p-Anisaldehyde dimethyl acetal

Downstream raw materials:

methyl (E)-2-cyano-4-phenyl-4-(p-methoxyphenyl)-2-pentenoate

trans-1-cyano-1-(methoxycarbonyl)-2-methyl-2-phenyl-3-(p-methoxyphenyl)cyclopropane

cis-4-cyano-4-(methoxycarbonyl)-3-methyl-3-phenyl-5-(1-phenyl-1-(p-methoxyphenyl)ethyl)-1-pyrazoline

(E)-2-Methoxycarbonyl-3-(4-methoxyphenyl)oxirane-2-carbonitrile

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