6-Chloro-2-phenylimidazo[1,2-a]pyridine

Base Information

• Chemical Name: 6-Chloro-2-phenylimidazo[1,2-a]pyridine
• CAS No.: 168837-18-1
• Molecular Formula: C13H9ClN2
• Molecular Weight: 228.681
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID70351293
• Nikkaji Number: J1.118.404I
• Wikidata: Q82127598
• ChEMBL ID: CHEMBL1498292
• Mol file: 168837-18-1.mol

Synonyms:6-chloro-2-phenylimidazo[1,2-a]pyridine;168837-18-1;6-Chloro-2-phenyl-imidazo[1,2-a]pyridine;MFCD00269393;MLS001166252;SCHEMBL2404662;CHEMBL1498292;DTXSID70351293;HMS1613O03;HMS2851K07;CCG-19985;STK809918;AKOS000416522;SMR000549983;CS-0126888;FT-0743608;VU0417689-3;1P-091;D70147;A882146;SR-01000487590;SR-01000487590-1;F0919-1752

Chemical Property of 6-Chloro-2-phenylimidazo[1,2-a]pyridine

Chemical Property:

• Melting Point: 205-207℃
• Refractive Index: 1.654
• PKA: 5.06±0.50(Predicted)
• PSA: 17.30000
• Density: 1.26 g/cm³
• LogP: 3.65470
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 4.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 228.0454260
• Heavy Atom Count: 16
• Complexity: 240

Purity/Quality:

99%, ^*data from raw suppliers

6-Chloro-2-phenylimidazo[1,2-a]pyridine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C2=CN3C=C(C=CC3=N2)Cl

Technology Process of 6-Chloro-2-phenylimidazo[1,2-a]pyridine

There total 20 articles about 6-Chloro-2-phenylimidazo[1,2-a]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

5-chloro-2-pyridylamine (1072-98-6) + 2,2-dimethoxy-2-phenylethyl 4-methylbenzenesulfonate → 6-chloro-2-phenylimidazo[1,2-a]pyridine (168837-18-1)

Guidance literature:

With scandium tris(trifluoromethanesulfonate); In acetonitrile; at 120 ℃; for 24h;

DOI:10.1021/acs.orglett.5b02966

Reference yield: 85.0%

5-chloro-2-pyridylamine (1072-98-6) + α-bromoacetophenone (70-11-1) → 6-chloro-2-phenylimidazo[1,2-a]pyridine (168837-18-1)

Guidance literature:

In neat (no solvent); at 65 ℃; for 0.333333h; under 750.075 Torr; Microwave irradiation; Green chemistry;

DOI:10.3184/174751916X14683327937934

Reference yield: 81.0%

5-chloro-2-pyridylamine (1072-98-6) + acetophenone (98-86-2) → 6-chloro-2-phenylimidazo[1,2-a]pyridine (168837-18-1)

Guidance literature:

acetophenone; With 1-butyl-3-methylimidazolium tribromide; In neat (no solvent); at 30 ℃; for 0.0833333h;

5-chloro-2-pyridylamine; With sodium carbonate; In neat (no solvent); at 30 ℃; for 0.666667h;

DOI:10.3390/molecules171113368

upstream raw materials:

5-chloro-2-pyridylamine

α-bromoacetophenone

acetophenone

1-phenyl-2-(p-tolylsulfonyloxy)ethanone

Downstream raw materials:

[6-chloro-2-phenylimidazo[1,2-a]pyridin-3-ylmethyl]-dimethylamine

(6-Chloro-2-phenyl-imidazo[1,2-a]pyridin-3-yl)-acetic acid

2-(6-chloro-2-phenyl-imidazo[1,2-a]pyridin-3-yl)-acetamide

C₁₈H₁₂ClN₃

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