3-FLUOROPYRROLIDINE HYDROCHLORIDE

Base Information

• Chemical Name: 3-FLUOROPYRROLIDINE HYDROCHLORIDE
• CAS No.: 169750-17-8
• Molecular Formula: C4H8FN.ClH
• Molecular Weight: 125.57200
• Hs Code.: 2933998090
• Mol file: 169750-17-8.mol

Synonyms:(RS)-3-Fluoro-pyrrolidine HCl;3-FLUOROPYRROLIDINE HCL;3-fluoropyrrolidine hydrochloride;r-(-)-3-fluoropyrrolidine hydrochloride;

Chemical Property of 3-FLUOROPYRROLIDINE HYDROCHLORIDE

Chemical Property:

• PSA: 12.03000
• Density: 1.05
• LogP: 1.44860
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

3-Fluoropyrrolidinehydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-FLUOROPYRROLIDINE HYDROCHLORIDE

There total 9 articles about 3-FLUOROPYRROLIDINE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.6%

tert-butyl 3-fluoropyrrolidine-1-carboxylate (518063-52-0) → 3-fluoropyrrolidine hydrochloride (136725-53-6,169750-17-8,136725-55-8)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 0 - 20 ℃; for 1h;

Reference yield: 95.6%

tert-butyl (S)-3-fluoropyrrolidine-1-carboxylate (479253-00-4) → (S)-3-fluoropyrrolidine hydrochloride (136725-53-6,169750-17-8,136725-55-8)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 0 - 20 ℃; for 1h;

Reference yield: 95.6%

(R)-1-N-tert-butoxycarbonyl-3-fluoropyrrolidine (876617-25-3) → (3R)-3-fluoropyrrolidine hydrochloride (136725-53-6,169750-17-8,136725-55-8)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 0 - 20 ℃; for 1h;

upstream raw materials:

(R)-1-N-tert-butoxycarbonyl-3-fluoropyrrolidine

(S)-N-CBz-3-fluoropyrrolidine

tert-butyl (S)-3-fluoropyrrolidine-1-carboxylate

(3S)-3-fluoropyrrolidine

Downstream raw materials:

(S)-3-bromo-N-(5-(3-fluoro)pyrrolidin-1-yl)pentylbenzenesulfonamide

{2-amino-6-[2-((S)-3-fluoropyrrolidin-1-ylmethyl)phenyl]quinazolin-4-yl}-(1,3-dihydroisoindol-2-yl)methanone

1-[3-(tert-Butyl-dimethyl-silanyloxy)-propyl]-3-fluoro-pyrrolidine

tert-butyldimethylsilanol

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