Pyrazole, 1-(trimethylsilyl)-

Base Information

• Chemical Name: Pyrazole, 1-(trimethylsilyl)-
• CAS No.: 18156-75-7
• Molecular Formula: C6H12N2Si
• Molecular Weight: 140.26
• DSSTox Substance ID: DTXSID60342317
• Nikkaji Number: J120.824A
• Wikidata: Q82113029
• Mol file: 18156-75-7.mol

Synonyms:Pyrazole, 1-(trimethylsilyl)-;trimethyl(pyrazol-1-yl)silane;1-(Trimethylsilyl)-1H-pyrazole;18156-75-7;Pyrazole, TMS derivative;1H-Pyrazole, 1-(trimethylsilyl)-;N-trimethylsilylpyrazole;1-(Trimethylsilyl)pyrazole;trimethyl(1-pyrazolyl)silane;1-Trimethylsilanyl-1H-pyrazole;SCHEMBL1720538;DTXSID60342317;AKOS006275094;A812637

Chemical Property of Pyrazole, 1-(trimethylsilyl)-

Chemical Property:

• Boiling Point: 148 - 152 °C (760 mmHg)
• PSA: 17.82000
• LogP: 1.56610
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 140.076974926
• Heavy Atom Count: 9
• Complexity: 97.7

Purity/Quality:

1-(trimethylsilyl)-1H-Pyrazole 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C[Si](C)(C)N1C=CC=N1

Technology Process of Pyrazole, 1-(trimethylsilyl)-

There total 3 articles about Pyrazole, 1-(trimethylsilyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

NH-pyrazole (288-13-1) + 1,1,1,3,3,3-hexamethyl-disilazane (999-97-3) → 1-trimethylsilylpyrazole (18156-75-7)

Guidance literature:

With ammonium sulfate; for 12h; Heating;

Reference yield:

NH-pyrazole (288-13-1) + chloro-trimethyl-silane (75-77-4) → 1-trimethylsilylpyrazole (18156-75-7)

Guidance literature:

With sodium hydride; Yield given. Multistep reaction; 1.) acetonitrile, 0 deg C, 24 h, 2.) dichloromethane, 20 deg C, 24 h;

Reference yield:

→ 1-trimethylsilylpyrazole (18156-75-7)

Guidance literature:

DOI:10.1016/S0022-328X(00)80564-1

upstream raw materials:

NH-pyrazole

chloro-trimethyl-silane

1,1,1,3,3,3-hexamethyl-disilazane

Downstream raw materials:

2-chloropyridine

2-fluoropyridine

2-(pyrazol-1-yl)pyridine

1-benzylpyrazole