2-(2-Methoxyphenoxy)ethanol

Base Information

• Chemical Name: 2-(2-Methoxyphenoxy)ethanol
• CAS No.: 18181-71-0
• Molecular Formula: C9H12O3
• Molecular Weight: 168.192
• Hs Code.: 2909499000
• DSSTox Substance ID: DTXSID70396669
• Nikkaji Number: J195.927A
• Mol file: 18181-71-0.mol

Synonyms:2-(2-methoxyphenoxy)ethanol;18181-71-0;2-(2-methoxyphenoxy)ethan-1-ol;Ethanol, 2-(2-methoxyphenoxy)-;2-Guaiacoxyethanol;2-(o-methoxyphenoxy) ethanol;SCHEMBL516162;2-(2-Methoxyphenoxy)-ethanol;DTXSID70396669;NGZBCWWJDDVXAQ-UHFFFAOYSA-N;MFCD01095842;AKOS000296375;CS-0196153;E89538

Chemical Property of 2-(2-Methoxyphenoxy)ethanol

Chemical Property:

• Boiling Point: 163-164 °C(Press: 15 Torr)
• PKA: 14.28±0.10(Predicted)
• PSA: 38.69000
• Density: 1.1561 g/cm3
• LogP: 1.06630
• XLogP3: 0.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 168.078644241
• Heavy Atom Count: 12
• Complexity: 116

Purity/Quality:

99.90% ^*data from raw suppliers

2-(2-Methoxyphenoxy)ethanol 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=CC=C1OCCO

Technology Process of 2-(2-Methoxyphenoxy)ethanol

There total 45 articles about 2-(2-Methoxyphenoxy)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

C19H24O6 → 2-(2-methoxyphenoxy)ethanol (18181-71-0) + 2-methoxy-phenol (90-05-1) + 1-(3,4-dimethoxyphenyl)ethanone (1131-62-0)

Guidance literature:

With hydridochlorotris(triphenylphosphine)ruthenium(II); [2-((diphenylphospino)methyl)-2-methyl-1,3-propanediyl]bis[diphenylphosphine]; In 5,5-dimethyl-1,3-cyclohexadiene; at 160 ℃; for 16h; Inert atmosphere; Glovebox;

DOI:10.1002/anie.201410620

Reference yield:

1-(3,4-dimethoxyphenyl)-2-(methoxyphenoxy)propane-1,3-diol (10535-17-8) → 2-methoxyphenoxy-3',4'-dimethoxyacetophenone (22675-96-3) + 2-(2-methoxyphenoxy)ethanol (18181-71-0) + 3,4-dimethoxy-benzaldehyde (120-14-9) + 2-methoxy-phenol (90-05-1)

Guidance literature:

With 1-hydroxytetraphenylcyclopentadienyl(tetraphenyl-2,4-cyclopentadien-1-one)-μ-hydrotetracarbonyldiruthenium(II); In 5,5-dimethyl-1,3-cyclohexadiene; at 140 ℃; for 20h; Reagent/catalyst; Temperature;

DOI:10.1246/cl.200037

Reference yield:

1-(3,4-dimethoxyphenyl)-2-(methoxyphenoxy)propane-1,3-diol (10535-17-8) → 2-methoxyphenoxy-3',4'-dimethoxyacetophenone (22675-96-3) + ethyl 3,4-dimethoxyphenyl ketone (1835-04-7) + 2-(2-methoxyphenoxy)ethanol (18181-71-0) + 3,4-dimethoxy-benzaldehyde (120-14-9) + 2-methoxy-phenol (90-05-1) + 1-(3,4-dimethoxyphenyl)ethanone (1131-62-0)

Guidance literature:

With 1-hydroxytetraphenylcyclopentadienyl(tetraphenyl-2,4-cyclopentadien-1-one)-μ-hydrotetracarbonyldiruthenium(II); In 1,3,5-trimethyl-benzene; at 140 ℃; for 20h; Reagent/catalyst; Temperature; Inert atmosphere;

DOI:10.1246/cl.200037

upstream raw materials:

oxirane

ethanol

sodium ethanolate

2-methoxy-phenol

Downstream raw materials:

2-(2-hydroxy-phenoxy)-ethanol

2-methoxy-phenol

2-(2-methoxy-phenoxy)-ethylamine

2-(2-methoxyphenoxy)-ethyl methanesulphonate

Refernces

• 1、 Hegg, Eric L.,Jackson, James E.,Klinger, Grace E.,Saffron, Christopher M.,Zhou, Yuting. "Multiple Mechanisms Mapped in Aryl Alkyl Ether Cleavage via Aqueous Electrocatalytic Hydrogenation over Skeletal Nickel". supporting information. p. 4037 - 4050. Retrieved 2020/03/10.
• 2、 -. "Method for depolymerizing lignin into aromatic compound through photocatalysis (by machine translation)". Paragraph 0047-0052. . Retrieved 2019/07/29.