2-ETHOXY-1H-ISOINDOLE-1,3(2H)-DIONE

Base Information

• Chemical Name: 2-ETHOXY-1H-ISOINDOLE-1,3(2H)-DIONE
• CAS No.: 1914-21-2
• Molecular Formula: C10H9NO3
• Molecular Weight: 191.186
• Hs Code.: 2925190090
• Mol file: 1914-21-2.mol

Synonyms:N-Ethoxyphthalimid;N-ethoxy-phthalimide;HMS1665K05;N-ethoxyphtalimide;N-Aethoxy-phthalimid;

Chemical Property of 2-ETHOXY-1H-ISOINDOLE-1,3(2H)-DIONE

Chemical Property:

• Melting Point: 97-98 °C
• Boiling Point: 305.7±25.0 °C(Predicted)
• PSA: 46.61000
• Density: 1.345 g/cm3(Temp: 22.4 °C)
• LogP: 1.17200

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-ETHOXY-1H-ISOINDOLE-1,3(2H)-DIONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-ETHOXY-1H-ISOINDOLE-1,3(2H)-DIONE

There total 13 articles about 2-ETHOXY-1H-ISOINDOLE-1,3(2H)-DIONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

N-hydroxyphthalimide (524-38-9) + ethanol (64-17-5) → N-ethoxyphthalimide (1914-21-2)

Guidance literature:

With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 0 - 20 ℃;

DOI:10.1021/ja3082186

Reference yield: 88.0%

N-hydroxyphthalimide (524-38-9) + ethyl iodide (75-03-6) → N-ethoxyphthalimide (1914-21-2)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In N,N-dimethyl-formamide; at 60 ℃; for 2h; Inert atmosphere;

Reference yield: 82.0%

ethyl bromide (74-96-4) + N-hydroxyphthalimide (524-38-9) → N-ethoxyphthalimide (1914-21-2)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In N,N-dimethyl-formamide; toluene; for 2h; Ambient temperature;

DOI:10.1080/00397919208021609

upstream raw materials:

ethyl bromide

N-hydroxyphthalimide

ethyl iodide

ethanol

Downstream raw materials:

O-ethyl hydroxylamine

O-ethylhydroxylamine hydrochloride

syn(Z)-N-[4-chloro-2-(ethoxyiminophenylmethyl)phenyl]trifluoromethanesulfonamide

cyclohexanone O-ethyl oxime