N-tert-Butyl-4-methoxybenzamide

Base Information

• Chemical Name: N-tert-Butyl-4-methoxybenzamide
• CAS No.: 19486-73-8
• Molecular Formula: C12H17NO2
• Molecular Weight: 207.272
• Hs Code.: 2924299090
• Mol file: 19486-73-8.mol

Synonyms:p-methoxy-N-t-butylbenzamide;N-t-butyl-p-methoxybenzamide;p-Anisamide,N-tert-butyl;N-tert-butyl-4-methoxy-benzamide;N-tert-butyl-p-anisamide;N-(tert-Butyl)-4-methoxybenzamide;4-methoxy-N-tert-butylbenzamide;

Chemical Property of N-tert-Butyl-4-methoxybenzamide

Chemical Property:

• Melting Point: 114-116 °C
• Boiling Point: 346.0±25.0 °C(Predicted)
• PKA: 15.11±0.46(Predicted)
• PSA: 38.33000
• Density: 1.019±0.06 g/cm3(Predicted)
• LogP: 2.61440
• Storage Temp.: Room temperature.

Purity/Quality:

≥95% ^*data from raw suppliers

N-tert-Butyl-4-methoxybenzamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-tert-Butyl-4-methoxybenzamide

There total 48 articles about N-tert-Butyl-4-methoxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-methoxy-benzoyl chloride (100-07-2) + tert-butylamine (75-64-9) → N-tert-butyl-4-methoxybenzamide (19486-73-8)

Guidance literature:

With sodium hydroxide; In dichloromethane;

DOI:10.1055/s-2001-10772

Reference yield: 98.0%

acetic acid tert-butyl ester (540-88-5) + 4-methoxy-benzaldehyde (123-11-5) → N-tert-butyl-4-methoxybenzamide (19486-73-8)

Guidance literature:

4-methoxy-benzaldehyde; With sodium azide; trifluorormethanesulfonic acid; acetic acid; at 40 ℃;

acetic acid tert-butyl ester; With trifluorormethanesulfonic acid; at 40 ℃;

DOI:10.1016/j.tetlet.2016.08.069

Reference yield: 98.0%

4-methoxy-benzaldehyde (123-11-5) + tert-butyl alcohol (75-65-0) → N-tert-butyl-4-methoxybenzamide (19486-73-8)

Guidance literature:

4-methoxy-benzaldehyde; With sodium azide; trifluorormethanesulfonic acid; acetic acid; at 40 ℃; for 2h;

tert-butyl alcohol; With trifluorormethanesulfonic acid; at 40 ℃; for 2h;

DOI:10.1016/j.tetlet.2016.08.069

upstream raw materials:

4-methoxy-benzoyl chloride

tert-butylamine

2-tert-butyl-3-(4-methoxyphenyl)-1,2-oxaziridine

N-(4-methoxybenzylidene)-2-methylpropan-2-amine

Downstream raw materials:

4-methoxy-2,N-dimethyl-benzamide

N-(tert-butyl)-4-methoxy-2-methylbenzamide

4-methoxy-2-(pyridin-2-yl)-N-tert-butylbenzamide

2-iodo-4-methoxy-N-tert-butylbenzamide

Refernces

• 1、 Hazarika, Nabajyoti,Baishya, Gakul. "One-pot sequential Schmidt and Ritter reactions for the synthesis of N-tert-butyl amides". . p. 5686 - 5690. Retrieved 2014.
• 2、 Bin, Zhengyang,Liao, Xingrong,Liu, Jiahui,Shen, Boming,Shi, Yang,Yan, Lipeng,Yang, Feng,Yang, Ge,Yang, Yudong,You, Jingsong,Yu, Peiyuan. "Insight into Regioselective Control in Aerobic Oxidative C-H/C-H Coupling for C3-Arylation of Benzothiophenes: Toward Structurally Nontraditional OLED Materials". supporting information. . Retrieved 2021/12/14.
• 3、 -. "Method for synthesizing amide by using methyl arene and amine in water phase". Paragraph 0015; 0061-0064. . Retrieved 2021/03/06.