Piperidine, 1-(4-methoxybenzoyl)-2,2,6,6-tetramethyl-

Base Information

• Chemical Name: Piperidine, 1-(4-methoxybenzoyl)-2,2,6,6-tetramethyl-
• CAS No.: 201008-68-6
• Molecular Formula: C17H25NO2
• Molecular Weight: 275.391
• DSSTox Substance ID: DTXSID70466997
• Nikkaji Number: J1.814.118C
• Wikidata: Q82293730
• Mol file: 201008-68-6.mol

Synonyms:Piperidine, 1-(4-methoxybenzoyl)-2,2,6,6-tetramethyl-;201008-68-6;DTXSID70466997

Chemical Property of Piperidine, 1-(4-methoxybenzoyl)-2,2,6,6-tetramethyl-

Chemical Property:

• XLogP3: 3.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 275.188529040
• Heavy Atom Count: 20
• Complexity: 338

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1(CCCC(N1C(=O)C2=CC=C(C=C2)OC)(C)C)C

Technology Process of Piperidine, 1-(4-methoxybenzoyl)-2,2,6,6-tetramethyl-

There total 6 articles about Piperidine, 1-(4-methoxybenzoyl)-2,2,6,6-tetramethyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

2,2,6,6-tetramethylpiperidinyl-lithium (38227-87-1) + 4-methoxy-benzaldehyde (123-11-5) → 4-Methoxybenzyl alcohol (105-13-5) + 1-(4-methoxybenzoyl)-2,2,6,6-tetramethylpiperidine (201008-68-6)

Guidance literature:

for 12h; Ambient temperature;

DOI:10.1016/S0040-4039(97)10369-0

Reference yield: 39.0%

4-methoxy-benzaldehyde (123-11-5) → 4-Methoxybenzyl alcohol (105-13-5) + 1-(4-methoxybenzoyl)-2,2,6,6-tetramethylpiperidine (201008-68-6)

Guidance literature:

With 2,2,6,6-tetramethylpiperidinyl-lithium; for 12h; Ambient temperature;

DOI:10.1016/S0040-4039(97)10369-0

Reference yield: 27.0%

2,2,6,6-tetramethyl-piperidine (768-66-1) + 4-methoxy-benzoyl chloride (100-07-2) → 1-(4-methoxybenzoyl)-2,2,6,6-tetramethylpiperidine (201008-68-6)

Guidance literature:

2,2,6,6-tetramethyl-piperidine; With sodium hydride; In toluene; at 20 ℃; for 0.166667h;

4-methoxy-benzoyl chloride; In toluene; for 24h; Heating;

DOI:10.1002/1099-0690(200211)2002:21<3558::AID-EJOC3558>3.0.CO;2-5

upstream raw materials:

2,2,6,6-tetramethylpiperidinyl-lithium

4-methoxy-benzaldehyde

4-methoxy-benzoyl chloride

2,2,6,6-tetramethyl-piperidine